POLYMERS

• US 20150306255A1
• Filed: 04/03/2015
• Published: 10/29/2015
• Est. Priority Date: 04/29/2014
• Status: Active Grant

• Current Assignee: Terumo Corporation
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Constant, Michael, Cruise, Gregory M., Chen, Samuel
• Granted Patent: US 10,092,663 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 49/0404 containing barium sulfate
• CPC Class Codes: A61K 49/0409 Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: D01D 5/00 Formation of filaments, threads, or the like
• CPC Class Codes: D01D 5/38 Formation of filaments, threads, or the like during polymerisation
• CPC Class Codes: D01F 1/10 Other agents for modifying properties
• CPC Class Codes: D01F 6/28 from copolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: D10B 2509/00 Medical; Hygiene

Abstract

Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer, at least one flexomer, and at least one visualization agent. Methods of making and using these polymers are also described.

Claims

1. A polymer filament comprising:

a reaction product of a prepolymer solution including at least one macromer, at least one flexomer, and at least one visualization agent.

2. The polymer filament of claim 1, wherein the at least one macromer is a multifunctional, low molecular weight, ethylenically unsaturated, shapeable macromer.

3. The polymer filament of claim 1, wherein the at least one macromer is a polyether.

4. The polymer filament of claim 1, wherein the at least one macromer is poly(ethylene glycol), poly(vinyl alcohol), poly(propylene glycol), poly(tetramethylene oxide), ethoxylated pentaerthritol, ethoxylated pentaerythritol tetra-acrylamide, or combinations thereof.

5. The polymer filament of claim 3, wherein the polyether is ethoxylated pentaerthritol.

6. The polymer filament of claim 1, wherein the at least one macromer has a concentration from about 5% to about 50% w/w.

7. The polymer filament of claim 1, wherein the at least one macromer has a molecular weight between about 700 g/mole to about 1,000 g/mole.

8. The polymer filament of claim 1, wherein the at least one flexomer is a difunctional, ethylenically unsaturated macromer.

9. The polymer filament of claim 1, wherein the at least one flexomer is poly(ethylene glycol), poly(propylene glycol), poly(vinyl alcohol), poly(tetramethylene oxide), linear polyethylene glycol or a combination thereof.

10. The polymer filament of claim 1, wherein the at least one flexomer has a concentration of between about 0.1% w/w and about 1% w/w of the prepolymer solution.

11. The polymer filament of claim 1, wherein the at least one flexomer has a molecular weight between about 8,000 g/mole to about 12,000 g/mole.

12. The polymer filament of claim 1, wherein the at least one visualization agent is barium, bismuth, tantalum, platinum, gold, iodine-containing molecules, barium sulfate, or a combination thereof.

13. The polymer filament of claim 1, wherein the polymer filament does not include metallic support members.

14. The polymer filament of claim 1, wherein the polymer filament is configured for delivery through a catheter.

15. A method of forming a polymer filament comprising:

reacting a prepolymer solution including at least one macromer, at least one flexomer, at least one visualization agent,

wherein the at least one macromer and the flexomer are different.

16. The method of claim 15, wherein the reacting is performed in a tubular structure.

17. The method of claim 16, wherein the tubular structure has a diameter between about 0.015 cm and 0.19 cm.

18. The method of claim 15, wherein the at least one macromer is a multifunctional, low molecular weight, ethylenically unsaturated, shapeable macromer.

19. The method of claim 15, wherein the at least one macromer is a polyether.

20. The method of claim 15, wherein the at least one macromer is poly(ethylene glycol), poly(vinyl alcohol), poly(propylene glycol), poly(tetramethylene oxide), ethoxylated pentaerthritol, ethoxylated pentaerythritol tetra-acrylamide, or combinations thereof.

21. The method of claim 19, wherein the polyether is ethoxylated pentaerthritol.

22. The method of claim 15, wherein the at least one macromer has a concentration from about 5% to about 50% w/w.

23. The method of claim 15, wherein the at least one macromer has a molecular weight between about 700 g/mole to about 1,000 g/mole.

24. The method of claim 15, wherein the at least one flexomer is a difunctional, ethylenically unsaturated macromer.

25. The method of claim 15, wherein the at least one flexomer is poly(ethylene glycol), poly(propylene glycol), poly(vinyl alcohol), poly(tetramethylene oxide), linear polyethylene glycol or a combination thereof.

26. The method of claim 15, wherein the at least one flexomer has a concentration of between about 0.1% w/w and about 1% w/w of the prepolymer solution.

27. The method of claim 15, wherein the at least one flexomer has a molecular weight between about 8,000 g/mole to about 12,000 g/mole.

28. The method of claim 15, wherein the at least one visualization agent is barium, bismuth, tantalum, platinum, gold, iodine-containing molecules, barium sulfate, or a combination thereof.

29. The method of claim 15, wherein the polymer filament does not include metallic support members.

30. The method of claim 15, wherein the polymer filament is configured for delivery through a catheter.