MINIATURIZED IMAGING DEVICES, SYSTEMS AND METHODS
First Claim
Patent Images
1. An imaging device, comprising:
- a base plate configured to be attached to a subject having a target region to be imaged; and
a device body having an image sensor configured to image the target region when the device body is connected to the base plate, wherein the device body is configured to be connected to and separated from the base plate in a reproducible manner.
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Abstract
The invention provides miniaturized devices, systems and methods for imaging of biological specimens. The devices and system provide accurate alignment and modular mounting of imaging components internally and in relation to the target subject. In some embodiments, the invention provides devices, systems and methods for in vivo fluorescent brain imaging in freely-behaving rodents.
26 Citations
29 Claims
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1. An imaging device, comprising:
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a base plate configured to be attached to a subject having a target region to be imaged; and a device body having an image sensor configured to image the target region when the device body is connected to the base plate, wherein the device body is configured to be connected to and separated from the base plate in a reproducible manner. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An imaging device, comprising:
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a focusing unit having an image sensor configured to image a target region; and an illumination unit comprising an optical element disposed along an image collection pathway from the target region to the image sensor, wherein the focusing unit and the illumination unit are movable relative to one another in an axial direction, and wherein a degree of the movement between the focusing unit and the illumination unit is restrained by a tamper restraint focus lock. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. An imaging device, comprising:
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a device body having a volume of 10 cubic centimeters or less, said device body comprising an image sensor configured to image a target region of a subject; and one or more objective lenses disposed along an image collection pathway from the target region to the image sensor, wherein the one or more objective lenses are configured to be connected and separated with the device body in a reproducible manner. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29)
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Specification