Novel Heterocyclic Compound Classes for Signaling Modulation
First Claim
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1. A compound of the Formula I, or a pharmaceutically acceptable salt thereof,
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Abstract
The invention relates to compounds of Formulas I-VII (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating cellular signaling pathways and biological processes associated therewith including inhibition of kinase activity such as PI-3 kinase or inhibition of bromodomain proteins or both at the same time as well as to therapeutic methods for treating a disease associated with aberrant PI3K and/or bromodomain proteins.
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17 Claims
- 1. A compound of the Formula I, or a pharmaceutically acceptable salt thereof,
- 5. A method for treating a disease in a human selected from cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infection, atherosclerosis, Type 2 diabetes, obesity, inflammatory disease, or Myc-dependent disorder comprising administering a compound of Formula I.
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