MULTI-MODE COMMUNICATION INGESTIBLE EVENT MARKERS AND SYSTEMS, AND METHODS OF USING THE SAME

• US 20150318901A1
• Filed: 04/29/2015
• Published: 11/05/2015
• Est. Priority Date: 03/05/2008
• Status: Active Grant

• Current Assignee: Otsuka Pharmaceutical Company Limited (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Inventors: Robertson, Timothy, Zdeblick, Mark
• Granted Patent: US 9,258,035 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/08 Sensors provided with means for identification, e.g. barcodes or memory chips
• CPC Class Codes: A61B 2562/162 Capsule shaped sensor housings, e.g. for swallowing or implantation
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/4833 Assessment of subject's compliance to treatment
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61B 5/6861 Capsules, e.g. for swallowing or implanting
• CPC Class Codes: G06K 7/10297 arrangements for handling protocols designed for non-contact record carriers such as RFIDs NFCs, e.g. ISO/IEC 14443 and 18092 cryptographic protocols H04L9/00; network security protocols H04L63/00; real-time communication protocols in data switching networks H04L65/00; network protocols for data switching network services H04L67/00
• CPC Class Codes: H04B 5/77 for interrogation

Abstract

A device including an integrated circuit, a partial power source, including first and second materials associated with the integrated circuit is disclosed. The first and second materials are configured to provide a voltage potential difference when in contact with a conductive fluid to power up the device. A signal amplification element secured around the integrated circuit relative to the first and second materials is configured to facilitate extension of a current flow path between the first and second materials. A modulator is configured to control conductance between the first and second materials to generate a detectable signal that is partially defined by the current flow extending through the conductive fluid. A communication module is coupled to the partial power source and is configured to communicate with a receiver and an antenna electrically coupled to the communication module, which uses the antenna to communicate with the receiver.

Claims

1. A device, comprising:

a integrated circuit component;

a partial power source comprising;

a first material associated with the integrated circuit component;

a second material different from the first material, wherein the second material is associated with the integrated circuit component, wherein the first and second materials are configured to provide a voltage potential difference when in contact with a conductive fluid and, upon contact with the conductive fluid, power up the device;

a signal amplification element secured around the integrated circuit component and positioned relative to the first and second materials, wherein the signal amplification element is configured to facilitate extension of a path of a current flow between the first material and the second material;

a modulator associated with the integrated circuit component and electrically connected to the first material and the second material, wherein the modulator is configured to control conductance between the first material and the second material to generate a detectable signal, wherein the detectable signal is at least partially defined by the current flow that extends through the conductive fluid;

at least one communication module coupled to the partial power source, wherein the at least one communication module is configured to communicate with a receiver; and

an antenna electrically coupled to the at least one communication module, wherein the at least one communication module uses the antenna to communicate with the receiver.

2. The device of claim 1, wherein the antenna is associated with a perimeter of the integrated circuit component.

3. The device of claim 1, wherein the antenna is a multi-turn antenna.

4. The device of claim 1, wherein the antenna comprises a multi-layer antenna.

5. The device of claim 1, comprising an insulating layer introduced over the antenna to extend range.

6. The device of claim 1, wherein the antenna matches the refractive index of a body to facilitate interbody, intrabody, and extrabody communications.

7. The device of claim 1, further comprising a power storage unit associated with the integrated circuit component for receiving power through the antenna and storing the power.

8. The device of claim 7, wherein the at least one communication module is powered by the power storage unit when the device is in a non-conducting environment.

9. The device of claim 1, wherein the detectable signal comprises a detectable electrical current, and wherein the modulator encodes information in the detectable electrical current by altering the conductance between the first material and the second material.

10. The device of claim 1, wherein the at least one communication module comprises a conductive communication module and a non-conductive communication module.

11. The device of claim 1, wherein the modulator is powered by the partial power source when the device is in contact with the conductive fluid.

12. The device of claim 1, further comprising an active pharmaceutical agent.

13. The device of claim 1, wherein the ingestible component comprises a physiologically acceptable vehicle.

14. A device comprising:

a integrated circuit component;

a first power source comprising;

a first material associated with the integrated circuit component;

a second material different from the first material, wherein the second material is associated with the integrated circuit component, wherein the first and second materials are configured to provide a voltage potential difference when in contact with a conductive fluid and, upon contact with the conductive fluid, power up the device; and

a signal amplification element secured around the integrated circuit component and positioned relative to the first and second materials, wherein the signal amplification element is configured to facilitate extension of a path of a current flow between the first material and the second material;

a modulator associated with the integrated circuit component and electrically connected to the first material and the second material, wherein the modulator is configured to control conductance between the first material and the second material to generate a detectable signal, wherein the detectable signal is at least partially defined by the current flow that extends through the conductive fluid;

a conductive communication module electrically coupled to the first power source;

a second power source comprising an antenna; and

a non-conductive communication module electrically coupled to the second power source.

15. The device of claim 14, wherein the integrated circuit comprises a layer of metal that is patterned with the antenna.

16. The device of claim 15, wherein the layer of metal provides a substrate for attaching a cathode and serves as a current collector for extracting electrical energy from the antenna.

17. The device of claim 16, wherein the layer of metal is patterned with the antenna.

18. The device of claim 17, wherein the antenna comprises a multi-turned, spiral-patterned design.

19. The device of claim 18, wherein the antenna becomes shorted when the device is immersed in the conductive fluid, thus permitting the non-conductive communication module to function in a dry environment but not in a liquid environment inside the body.

20. The device of claim 19, wherein the dry environment is a manufacturing environment or a pharmacy environment.

21. A device comprising:

a integrated circuit component;

a partial power source comprising;

a first material associated with the integrated circuit component;

a second material different from the first material, wherein the second material is associated with the integrated circuit component, wherein the first and second materials are reactive with a conductive fluid to provide a voltage potential difference when in contact with the conductive fluid and, upon contact with the conductive fluid, power up the device, and wherein the first material comprises a reaction species that is released into the conductive fluid when the first material reacts with the conductive fluid; and

a modulator associated with the integrated circuit component and electrically connected to the first material and the second material, wherein the modulator is configured to control conductance between the first material and the second material to control power supplied to the device and generate a detectable signal, wherein the detectable signal is at least partially defined by a current flow that extends through the conductive fluid, and wherein the current flow comprises the reaction species;

a signal amplification element secured around the integrated circuit component and positioned relative to the first and second materials, wherein the signal amplification element is configured to facilitate extension of a path of a current flow between the first material and the second material, and wherein the signal amplification element defines first and second surfaces;

at least one communication module coupled to the partial power source, wherein the at least one communication module is configured to communicate with a receiver; and

an antenna located on at least one of the first or second surface of the signal amplification element about the respective first or second material, wherein the antenna is electrically coupled to the communication module via first and second electrical connections, and wherein the at least one communication module uses the antenna to communicate with the receiver.

22. The device of claim 21, further comprising a power storage unit associated with the integrated circuit component for receiving power through the antenna and storing the power.

23. The device of claim 22, wherein the at least one communication module is powered by the power storage unit when the device is in a non-conducting environment.

24. The device of claim 21, wherein the detectable signal comprises a detectable electrical current, and wherein the modulator encodes information in the detectable electrical current by altering the conductance between the first material and the second material.

25. The device of claim 21, wherein the at least one communication module comprises a conductive communication module and a non-conductive communication module.