DETECTION OF RESPIRATORY DISORDERS

• US 20150320338A1
• Filed: 12/09/2013
• Published: 11/12/2015
• Est. Priority Date: 12/19/2012
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: KANE, MICHAEL THOMAS, SHANKAR, SANKARASUBRAHMANI UDAY
• Granted Patent: US 11,344,224 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0826 Detecting or evaluating apnoea events A61B5/4818 takes precedence
• CPC Class Codes: A61B 5/085 Measuring impedance of respiratory organs or lung elasticity
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2016/0042 in the expiratory circuit
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/332 Force measuring means
• CPC Class Codes: A61M 2230/46 Resistance or compliance of the lungs
• CPC Class Codes: A61M 2230/63 Motion, e.g. physical activity

Abstract

Systems and methods for monitoring pulmonary edema and/or pulmonary congestion are based on changes in impedance parameters that are indicative of lung impedance of a patient. Early detection of changes in the status of a patient pertaining to pulmonary edema and/or pulmonary congestion may be especially beneficial for heart failure patients. Quantification is based on differentials, e.g. within a span of 24 hours, of one or more lung impedance parameters.

Claims

1. A system to monitor a characteristic of a lung, the system comprising:

a pressure generator configured to generate a pressurized flow of breathable gas for delivery to the airway of a subject;

one or more sensors configured to generate one or more output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas; and

one or more processors configured to execute computer program modules, the computer program modules comprising;

a control module configured to control the pressure generator to adjust one or more levels of the one or more gas parameters of the pressurized flow of breathable gas,

a parameter determination module configured to determine a respiratory parameter, wherein the parameter determination module is further configured to determine a monitoring parameter that reflects a change between a first measurement of the respiratory parameter and a second measurement of the respiratory parameter, and wherein the first measurement is taken before a sleep session, and wherein the second measurement is taken subsequent to a sleep session, and

a detection module configured to detect, monitor, and/or quantify a characteristic of a lung of the subject based on the monitoring parameter.

2. The system of claim 1, further comprising a trending module configured to detect one or more trends in the monitoring parameter, wherein quantification by the detection module is further based on a detected trend.

3. The system of claim 1, further comprising:

a perturbation module configured to determine one or more perturbation parameters defining perturbations to be applied to the levels of the one or more gas parameters of the pressurized flow of breathable gas,

wherein the control module is configured to control the pressure generator such that such that the levels of the one or more gas parameters of the pressurized flow of breathable gas include the perturbations defined by the perturbation module.

4. The system of claim 1, wherein the change between the first measurement and the second measurement reflects an accumulation of pulmonary fluid.

5. The system of claim 1, wherein the change between the first measurement and the second measurement reflects a redistribution of pulmonary fluid.

6. The system of claim 1, wherein the characteristic of a lung of the subject based determined by the detection module includes pulmonary edema, airway resistance, and/or pulmonary congestion.

7. A method for detecting lung characteristics and/or trends in a characteristic of a lung of a subject, the method comprising:

generating one or more output signals conveying information related to one or more gas parameters of a pressurized flow of breathable gas;

determining a first measurement of a respiratory parameter of the subject, wherein the first measurement is based on the one or more generated output signals;

determining a second measurement of the respiratory parameter of the subject, wherein the second measurement is based on the one or more generated output signals, and wherein the first measurement is taken before a sleep session, and wherein the second measurement is taken subsequent to a sleep session;

determining a monitoring parameter that reflects the change between the first measurement and the second measurement; and

detecting a characteristic of a lung of the subject based on the monitoring parameter.

8. The method of claim 7, further comprising:

detecting one or more trends in the monitoring parameter,

wherein the step of detecting a characteristic of a lung of the subject is further based on a detected trend.

9. The method of claim 7, further comprising:

determining one or more perturbation parameters defining perturbations to be applied to one or more levels of the one or more gas parameters of the pressurized flow of breathable gas.

10. The method of claim 7, wherein the change between the first measurement and the second measurement reflects an accumulation of pulmonary fluid.

11. The method of claim 7, wherein the change between the first measurement and the second measurement reflects a redistribution of pulmonary fluid.

12. The method of claim 7, wherein the characteristic of the lung of the subject includes pulmonary edema, airway resistance, and/or pulmonary congestion.

13. A system configured to monitor a characteristic of a lung, the system comprising;

means for generating a pressurized flow of breathable gas for delivery to the airway of a subject;

means for generating one or more output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas;

means for adjusting one or more levels of the one or more gas parameters of the pressurized flow of breathable gas;

means for determining a first measurement of a respiratory parameter of the subject, wherein the first measurement is based on the one or more generated output signals;

means for determining a second measurement of the respiratory parameter, wherein the second measurement is based on the one or more generated output signals, and wherein the first measurement is taken before a sleep session, and wherein the second measurement is taken subsequent to a sleep session;

means for determining a monitoring parameter that reflects the change between the first measurement and the second measurement; and

means for detecting, monitoring, and/or quantifying a characteristic of a lung of the subject based on the monitoring parameter.

14. The system of claim 13, further comprising:

means for detecting one or more trends in the monitoring parameter,

wherein operation of the means for quantifying pulmonary edema and/or pulmonary congestion is further based on a detected trend.

15. The system of claim 13, further comprising:

means for determining one or more perturbation parameters defining perturbations to be applied to the levels of the one or more gas parameters of the pressurized flow of breathable gas,

wherein the means for adjusting the one or more levels of the one or more gas parameters operates such that the levels of the one or more gas parameters of the pressurized flow of breathable gas include the defined perturbations.

16. The system of claim 13, wherein the change between the first measurement and the second measurement reflects an accumulation of pulmonary fluid.

17. The system of claim 13, wherein the change between the first measurement and the second measurement reflects a redistribution of pulmonary fluid.

18. The method of claim 13, wherein the characteristic of the lung of the subject includes pulmonary edema, airway resistance, and/or pulmonary congestion.