IMAGING METHOD FOR RESECTED MATTER AND/OR FOR A RESECTION BED AND IMAGE GENERATION DEVICE FOR CARRYING OUT SUCH AN IMAGING METHOD

• US 20150327767A1
• Filed: 12/18/2013
• Published: 11/19/2015
• Est. Priority Date: 12/18/2012
• Status: Abandoned Application

• Current Assignee: Carl Zeiss AG (Carl-Zeiss-Stiftung), Carl Zeiss Meditec AG (Carl-Zeiss-Stiftung)
• Original Assignee: Carl Zeiss AG (Carl-Zeiss-Stiftung), Carl Zeiss Meditec AG (Carl-Zeiss-Stiftung)
• Inventors: HELLMICH, Wibke, SCHMITT-MANDERBACH, Tobias, FUCHS, Holger, RUSSMANN, Christoph, NIETEN, Christoph
• Application Number:
  US14/652,902
• Publication Number:
  US 20150327767A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 2005/1098 Enhancing the effect of the particle by an injected agent or implanted device
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61N 5/1039 using functional images, e.g. PET or MRI
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids

Abstract

Provided is an imaging method in which a surface of resected matter is imaged in first images with a photoacoustic image generation method down to a first predetermined depth such that in the first images there is a contrast between pathological tissue, in particular cancerous tissue, and non-pathological tissue.

Claims

1-15. -15. (canceled)

16. An imaging method, comprising:

imaging a surface of a resected matter in a first set of images via photoacoustic image generation down to a first predetermined depth such that in the first set of images there is a contrast between pathological tissue and non-pathological tissue.

17. The imaging method of claim 16, wherein a bowl-shaped volume area of the resected matter is imaged via photoacoustic image generation, and wherein the thickness of the bowl-shaped volume area corresponds to the first predetermined depth.

18. The imaging method of claim 17, further comprising administering at least one contrast agent to the resected matter to increase the contrast.

19. The imaging method of claim 18, wherein the at least one contrast agent is an encapsulated contrast agent.

20. The imaging method of claim 18, wherein at least one of the at least one contrast agent is administered as first contrast agent after removal of the resected matter.

21. The imaging method of claim 18, wherein at least one of the at least one contrast agent is administered as second contrast agent before removal of the resected matter.

22. The imaging method of claim 18, wherein the resected matter is exposed to a first electromagnetic radiation with a first wavelength in order to generate first pressure waves, the method further comprising selecting the at least one contrast agent to define the first wavelength.

23. The imaging method of claim 16, further comprising administering at least one contrast agent to the resected matter to increase the contrast.

24. The imaging method of claim 23, wherein the at least one contrast agent is an encapsulated contrast agent.

25. The imaging method of claim 23, wherein at least one of the at least one contrast agent is administered as first contrast agent after removal of the resected matter.

26. The imaging method of claim 23, wherein at least one of the at least one contrast agent is administered as second contrast agent before removal of the resected matter.

27. The imaging method of claim 23, wherein the resected matter is exposed to a first electromagnetic radiation with a first wavelength in order to generate first pressure waves, the method further comprising selecting the at least one contrast agent to define the first wavelength.

28. The imaging method of claim 16, further comprising generating a three-dimensional recording from the first images.

29. The imaging method of claim 16, further comprising:

removing at least some of the resected matter to form a resection bed; and

imaging a surface of the resection bed in a second set of images by imaging down to a second predetermined depth via photoacoustic image generation such that in the second set of images there is a contrast between pathological tissue and non-pathological tissue.

30. The imaging method of claim 29, wherein a bowl-shaped volume area of the resection bed is imaged via photoacoustic image generation, and wherein the thickness of the bowl-shaped volume area of the resection bed corresponds to the second predetermined depth.

31. The imaging method of claim 30, further comprising:

administering a medicament to the resection bed; and

exposing the pathological tissue to the predetermined type of radiation in order to activate an effect of the medicament.

32. The imaging method of claim 31, further comprising at least one of:

selectively administering the medicament locally to the pathological tissue based on the second images; and

selectively exposing the pathological tissue locally to the predetermined type of radiation based on the second images.

33. The imaging method of claim 31, wherein the predetermined type of radiation is a member of the group consisting of ultrasound, electromagnetic radiation or ionizing radiation.

34. The imaging method of claim 29, further comprising:

administering a medicament to the resection bed; and

exposing the pathological tissue to the predetermined type of radiation in order to activate an effect of the medicament.

35. The imaging method of claim 34, further comprising at least one of:

selectively administering the medicament locally to the pathological tissue based on the second images; and

selectively exposing the pathological tissue locally to the predetermined type of radiation based on the second images.

36. The imaging method of claim 34, wherein the predetermined type of radiation is a member of the group consisting of ultrasound, electromagnetic radiation or ionizing radiation.

37. The imaging method of claim 29, further comprising selectively exposing the pathological tissue in the resection bed to ionizing radiation with a probe based on the second images.

38. Image generation system for carrying out an imaging method, the imaging method comprising imaging a surface of a resected matter in a first set of images via photoacoustic image generation down to a first predetermined depth such that in the first set of images there is a contrast between pathological tissue and non-pathological tissue, the system comprising:

an optics module to expose the surface of the resected matter to electromagnetic radiation;

an acoustics module to detect the generated pressure waves;

a holder configured to provide relative movement between the optics module and the resected matter; and

an image generator configured to generate the first images based on the detected pressure waves.