METHOD FOR PHASE TRANSFER SYNTHESIS OF ORGANIC PEROXIDES
First Claim
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1. A process for synthesizing an organic peroxide, said process comprising:
- reacting an organic hydroperoxide with at least one organic reactant in a multiphase reaction mixture to thereby form an organic peroxide,wherein said multiphase reaction mixture comprises a first reaction phase and a second reaction phase at least partially immiscible in said first reaction phase, wherein said organic hydroperoxide is more miscible in one of said first and second reaction phases than in the other,wherein said multiphase reaction mixture further comprises at least one catalyst for facilitating mass transfer between said first and said second reaction phases,wherein said reacting is carried out in a reaction zone comprising one or more reaction channels, wherein at least one of said reaction channels has one or more of the following characteristics—
(i) a total channel volume of less than 75 mL;
(ii) a length-to-width ratio of at least 20;
1; and
/or(iii) an average channel cross-sectional area of less than 10 mm2.
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Abstract
Processes and systems for synthesizing organic peroxides are provided. One or more of the reactions described herein may be performed in a continuous reactor, optionally including at least one microscale reaction channel. Additionally, at least one phase transfer catalyst may be used to facilitate reaction of components present in a multiphase reaction mixture.
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Citations
21 Claims
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1. A process for synthesizing an organic peroxide, said process comprising:
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reacting an organic hydroperoxide with at least one organic reactant in a multiphase reaction mixture to thereby form an organic peroxide, wherein said multiphase reaction mixture comprises a first reaction phase and a second reaction phase at least partially immiscible in said first reaction phase, wherein said organic hydroperoxide is more miscible in one of said first and second reaction phases than in the other, wherein said multiphase reaction mixture further comprises at least one catalyst for facilitating mass transfer between said first and said second reaction phases, wherein said reacting is carried out in a reaction zone comprising one or more reaction channels, wherein at least one of said reaction channels has one or more of the following characteristics— (i) a total channel volume of less than 75 mL; (ii) a length-to-width ratio of at least 20;
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/or(iii) an average channel cross-sectional area of less than 10 mm2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A process for synthesizing an organic peroxide, said process comprising:
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(a) providing a first reactant mixture comprising at least one organic reactant selected from the group consisting of alcohols, ketones, acids, esters, ethers, or halides or anhydrides thereof; (b) providing a second reactant mixture comprising at least one pH modifying agent, wherein said first and said second reactant mixtures are at least partially immiscible with one another, and wherein at least one of said first and second reactant mixtures include at least one organic hydroperoxide; (c) reacting at least a portion of said organic reactant with said organic hydroperoxide in a reaction zone in the presence of at least one phase transfer catalyst to thereby provide said organic peroxide, wherein said reaction zone is at least partially defined within at least one continuous microscale reactor. - View Dependent Claims (14, 15, 16, 17)
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18. A process for synthesizing an organic peroxide, said process comprising:
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(a) reacting an organic hydroperoxide with at least one organic reactant in multiphase reaction mixture to thereby form an organic peroxide; and (b) recovering at least a portion of said organic peroxide from at least a portion of said reaction mixture, wherein said multiphase reaction mixture comprises a first reaction phase and a second reaction phase at least partially immiscible in said first reaction phase, wherein said organic hydroperoxide is more miscible in one of said first and second reaction phases than in the other, wherein said multiphase reaction mixture further comprises at least one catalyst for facilitating mass transfer between said first and said second reaction phases, and wherein each of said reacting and said recovering is performed in a continuous manner. - View Dependent Claims (19, 20, 21)
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Specification