MESENCHYMAL STEM CELL AND THE METHOD OF USE THEREOF
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Abstract
Demyelinated axons were remyelinated in the demyelinated rat model by collecting bone marrow cells from mouse bone marrow and transplanting the mononuclear cell fraction separated from these bone marrow cells.
2 Citations
23 Claims
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1. (canceled)
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2. A cell population isolated from bone marrow or cord blood comprising mesenchymal stem cells,
wherein said mesenchymal stem cells are SH2(+), SH3(+), SH4(+), CD29(+), CD44(+), CD14(− - ), CD34(−
), and CD45(−
), andwherein cells within said cell population are capable of differentiating into neurons or glia cells. - View Dependent Claims (4, 5, 6)
- ), CD34(−
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3. A method for treating neurodegeneration, comprising
isolating a cell population from bone marrow, wherein said cell population comprises mesenchymal stem cells that are SH2(+), SH3(+), SH4(+), CD29(+), CD44(+), CD14(− - ), CD34(−
), and CD45(−
) and said isolation does not exclude hematopoietic cells from said cell population; andinjecting an effective amount of said isolated cell population into a patient in need of said treatment, wherein said effective amount of said isolated cell population is effective at treating said patient'"'"'s neurodegeneration. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
- ), CD34(−
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7. A mononuclear cell fraction comprising cells capable of differentiating into neurons or glia cells, wherein said fraction is prepared by
obtaining bone marrow cells or cord blood cells, diluting the bone marrow cells, separating a mononuclear cell fraction, collecting said mononuclear cell fraction.
Specification