APPARATUS AND METHOD FOR PLATELET FUNCTION AND DRUG REPSONSE TESTING BASED ON MICROFLUIDIC CHIP
First Claim
1. An apparatus for testing a function and a drug response of a platelet based on a microfluidic chip comprising:
- a measuring device containing a blood sample and measuring aggregation and adhesion of a platelet generated by flow of the blood sample; and
a fluid driving device which is connected to the measuring device and generates a oscillating shear flow of the blood sample.
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Abstract
The present invention relates to an apparatus and a method for testing a function and a drug response of a platelet based on a microfluidic chip. The apparatus for test comprises a measuring device containing a blood sample and measuring aggregation and adhesion of a platelet generated by flow of the blood sample; and a fluid driving device which is connected to the measuring device and generates a oscillating shear flow of the blood sample. Therefore, activation of factors such as a platelet and von Willebrand factor (vWF) etc. can be activated uniformly and completely, and a repeatability of the platelet aggregation can be increased.
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Citations
20 Claims
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1. An apparatus for testing a function and a drug response of a platelet based on a microfluidic chip comprising:
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a measuring device containing a blood sample and measuring aggregation and adhesion of a platelet generated by flow of the blood sample; and a fluid driving device which is connected to the measuring device and generates a oscillating shear flow of the blood sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for a platelet function and drug response test based on a microfluidic chip comprising:
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injecting a blood sample into sample containers which are disposed both sides; generating a oscillating shear flow of the blood sample through a micro channel connected to the sample container; supplying a drug in a measuring chamber which is positioned at the central part of the micro channel, the drug reacts the platelet; and measuring a change which is caused by an aggregation and adhesion of a platelet in the measuring chamber.
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Specification