ANTI-MIGRATION STENT

• US 20150342760A1
• Filed: 05/27/2015
• Published: 12/03/2015
• Est. Priority Date: 06/02/2014
• Status: Abandoned Application

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Christakis, Laura Elizabeth, Fater, Michelle
• Application Number:
  US14/722,534
• Publication Number:
  US 20150342760A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/945 hardenable, e.g. stents formed in situ
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2250/0025 differing in roughness
• CPC Class Codes: A61F 2250/0039 differing in diameter
• CPC Class Codes: A61F 2250/0048 differing in mechanical expandability, e.g. in mechanical, self- or balloon expandability
• CPC Class Codes: Y10S 623/00 Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
• CPC Class Codes: Y10S 977/905 Specially adapted for travel through blood circulatory system

Abstract

Embodiments of the disclosure relate to devices, systems and methods of use and manufacture. One such device is a stent. The stent includes a stent body and a coating over at least a portion of the stent body. The coating includes a shape memory polymer having an outer surface. The outer surface defines a first configuration and a second configuration. In the first configuration the outer surface is smooth. In the second configuration, the outer surface includes a micro pattern.

Claims

1. A stent comprising:

a stent body; and

a coating over at least a portion of the stent body, the coating comprising a shape-memory polymer defining an outer surface, the outer surface having a first configuration and a second configuration;

in the first configuration the outer surface being smooth and in the second configuration, the outer surface having a micro pattern.

2. The stent of claim 1, wherein the stent body is formed from a polymeric material.

3. The stent of claim 1, wherein the stent body is formed from a metallic material.

4. The stent of claim 1, wherein the stent body is self-expanding.

5. The stent of claim 1, wherein the stent body is balloon-expandable.

6. The stent of claim 1, wherein the outer surface of the shape-memory polymer transitions from the first configuration to the second configuration upon application of heat to the shape-memory polymer.

7. The stent of claim 1 wherein the micro pattern defines a plurality of holes extending through the coating, the holes having a cross-section of about 100 nanometers or less.

8. The stent of claim 1 wherein the micro pattern is a repeating pattern along the surface of the coating and at least 75% of the holes are spaced between about 1 and 100 microns apart.

9. A stent delivery device comprising:

a catheter and a stent, the catheter having an expandable balloon;

the stent having a stent body and a coating over at least a portion of the stent body, the coating comprising a shape-memory polymer defining an outer surface, the outer surface having a first configuration and a second configuration; and

in the first configuration the outer surface being smooth and in the second configuration, the outer surface having a micro pattern;

wherein, in the delivery configuration, the stent is disposed over at least a portion of the expandable balloon.

10. The stent delivery device of claim 9, wherein the expandable balloon comprises a conductive covering and the stent is disposed around the conductive covering in the delivery configuration.

11. The stent delivery device of claim 10, wherein the outer surface of the shape-memory polymer transitions from the first configuration to the second configuration upon application of heat to the shape-memory polymer via the conductive covering.

12. The stent delivery device of claim 11, wherein the conductive covering is arranged in a plurality of adjacent circumferential rings.

13. The stent delivery device of 11, wherein, in the second configuration, the micro pattern is defined by a plurality of micro pillars.

14. A stent comprising:

a stent body; and

a mucoadhesive coating over at least a portion of the stent body, the mucoadhesive coating formed from a polymeric material and defining a micro pattern, the micro pattern defining a plurality of holes extending through the mucoadhesive coating, the holes having a cross section less than or equal to 100 nanometers.

15. The stent of claim 14, wherein the micro pattern is arranged in a repeating pattern along a surface of the mucoadhesive coating and at least 75% of the holes are spaced between 1 and 100 microns from any adjacent hole.

16. The stent of claim 15 wherein at least 90% of the holes are spaced between 1 and 100 microns from any adjacent hole.

17. The stent of claim 14, wherein the mucoadhesive coating comprises thiolated chitosan molecules, polymers of ethyl acetate, polycarbophil, and mixtures thereof.

18. The stent of claim 14, wherein the holes are evenly distributed along the stent body.

19. The stent of claim 14 wherein the holes are packed with a secondary material.

20. The stent of claim 19 wherein the secondary material is a degradable material.