ICOS Critically Regulates the Expansion and Function of Inflammatory Human Th17 Cells
First Claim
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1. A method of immunotherapy comprising administering an ICOS stimulated T cell to a patient in need thereof.
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Abstract
The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.
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6 Claims
- 1. A method of immunotherapy comprising administering an ICOS stimulated T cell to a patient in need thereof.
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