SAMPLE CONCENTRATION DEVICE

• US 20150346166A1
• Filed: 01/15/2014
• Published: 12/03/2015
• Est. Priority Date: 01/18/2013
• Status: Active Grant

• Current Assignee: Shimadzu Corporation
• Original Assignee: Shimadzu Corporation
• Inventors: Morikawa, Tsuyoshi, Okada, Kohji
• Granted Patent: US 10,203,308 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: G01N 2030/027 Liquid chromatography
• CPC Class Codes: G01N 2033/0019 by preconcentration
• CPC Class Codes: G01N 30/24 Automatic injection systems
• CPC Class Codes: G01N 30/7233 interfaced to liquid or supercritical fluid chromatograph interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04
• CPC Class Codes: G01N 30/84 Preparation of the fraction to be distributed

Abstract

A controller for controlling the operations of an autosampler, a sample push unit, and a make-up unit includes a pump stop timing setting unit for setting a first timing T1 of completion of dilution of a sample, and a subsequent second timing T2 of completion of trapping of a sample in the trap column, a dilution control unit for causing a solvent delivery pump for make-up of the make-up unit to operate, and for stopping operation of the solvent delivery pump for make-up at the first timing T1 set by the pump stop timing setting unit, and a sample push control unit for causing a solvent delivery pump for sample push of the sample push unit to operate, and for stopping operation of the solvent delivery pump for sample push at the second timing T2 set by the pump stop timing setting unit.

Claims

1. A sample concentration device comprising:

an autosampler for injecting a certain volume of sample;

a trap column;

a sample push unit for delivering a sample injected by the autosampler to the trap column by a solvent delivery pump for sample push;

a make-up unit for compensating for a diluent by a solvent delivery pump for make-up with respect to a sample pushed out by the sample push unit; and

a controller for controlling operations of the autosampler, the sample push unit, and the make-up unit,

wherein the controller comprises

a pump stop timing setting unit for setting a first timing T1 of completion of dilution of a sample, and a subsequent second timing T2 of completion of trapping of a sample in the trap column,

a dilution control unit for causing the solvent delivery pump for make-up of the make-up unit to operate, and for stopping operation of the solvent delivery pump for make-up at the first timing T1 set by the pump stop timing setting unit, and

a sample push control unit for causing the solvent delivery pump for sample push of the sample push unit to operate, and for stopping operation of the solvent delivery pump for sample push at the second timing T2 set by the pump stop timing setting unit.

2. The sample concentration device according to claim 1, wherein the pump stop timing setting unit sets a timing calculated based on a sample injection volume as the timing T1, and sets a timing calculated based on a sample sweep volume as the timing T2.

3. The sample concentration device according to claim 2, wherein the pump stop timing setting unit stores in advance a timing T1 calculated based on a maximum sample injection volume and a timing T2 calculated based on a sample sweep volume, and when notified of a sample injection volume by the autosampler, calculates a timing T1 based on the notified sample injection volume and takes the timing T1 as a set value of the timing T1, and when not notified of a sample injection volume by the autosampler, takes the timing T1 stored in advance as a set value.

4. The sample concentration device according to claim 1, comprising

a probe for detecting a sample bulk end at a stage preceding the trap column,

wherein the pump stop timing setting unit sets a timing calculated based on a timing of a detection signal of the probe as the timing T1, and sets a timing calculated based on a sample sweep volume as the timing T2.

5. The sample concentration device according to claim 1, wherein the controller swiftly stops a time program and ends a concentration operation after stopping operation of the solvent delivery pump for sample push at the second timing T2.

6. The sample concentration device according to claim 2, wherein the controller swiftly stops a time program and ends a concentration operation after stopping operation of the solvent delivery pump for sample push at the second timing T2.

7. The sample concentration device according to claim 3, wherein the controller swiftly stops a time program and ends a concentration operation after stopping operation of the solvent delivery pump for sample push at the second timing T2.

8. The sample concentration device according to claim 4, wherein the controller swiftly stops a time program and ends a concentration operation after stopping operation of the solvent delivery pump for sample push at the second timing T2.