INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

• US 20150351683A1
• Filed: 08/19/2015
• Published: 12/10/2015
• Est. Priority Date: 02/26/2004
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Brauker, James H., Tapsak, Mark A., Saint, Sean T., Kamath, Apurv Ullas, Neale, Paul V., Simpson, Peter C., Mensinger, Michael Robert, Markovic, Dubravka
• Granted Patent: US 9,937,293 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0443 Modular apparatus
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 11/00 Sprayers or atomisers specially adapted for therapeutic purposes in general B05B; aerosol containers B65D83/14
• CPC Class Codes: A61M 15/0001 Details of inhalators; Constructional features thereof
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/63 for local operation

Abstract

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

Claims

1. A method for estimating glucose levels from an integrated glucose sensor and medicament delivery device, the method comprising:

receiving in a receiver a data stream from a glucose sensor, including one or more sensor data points;

receiving in the receiver medicament delivery data responsive to medicament delivery from a medicament delivery device;

evaluating medicament delivery data with glucose sensor data corresponding to delivery and release times of the medicament delivery data to determine individual metabolic patterns associated with medicament delivery; and

estimating glucose values responsive to individual metabolic patterns associated with the medicament delivery.

2. The method according to claim 1, wherein the individual'"'"'s metabolic patterns associated with medicament delivery are calculated using a pattern recognition algorithm.

3. The method according to claim 1, wherein the step of determining the individual'"'"'s metabolic patterns to medicament delivery is repeated when the receiver receives additional medicament delivery data.

4. The method according to claim 3, wherein the individual'"'"'s metabolic patterns are iteratively determined for a time period exceeding one week.

5. An integrated system for monitoring and treating diabetes, the system comprising:

a glucose sensor, wherein the glucose sensor substantially continuously measures glucose in a host for a period exceeding one week, and outputs a data stream, including one or more sensor data points;

a receiver operably connected to the glucose sensor, wherein the receiver is configured to receive the data stream; and

a medicament delivery device, wherein the delivery device is at least one of physically and operably connected to the receiver.

6. The integrated system according to claim 5, wherein the glucose sensor comprises an implantable glucose sensor.

7. The integrated system according to claim 5, wherein the glucose sensor comprises a long-term subcutaneously implantable glucose sensor.

8. The integrated system according to claim 5, wherein the medicament delivery device comprises a syringe detachably connectable to the receiver.

9. The integrated system according to claim 5, wherein the medicament delivery device comprises one or more transdermal patches detachably connectable to the receiver.

10. The integrated system according to claim 5, wherein the medicament delivery device comprises an inhaler or spray delivery device detachably connectable to the receiver.