DEVICES, SYSTEMS AND METHODS FOR HEART VALVE REPLACEMENT
First Claim
1. A device for repair or replacement of a native heart valve, the native heart valve having an annulus and leaflets coupled to the annulus, comprising:
- a valve support having an upstream end and a downstream end extending along a longitudinal axis, the valve support having an outer surface and an inner surface, wherein the inner surface is configured to support a prosthetic valve, and wherein the valve support has a cross-sectional shape;
an expandable ring-shaped retainer coupled to the upstream end of the valve support, the retainer configured to engage and seal with tissue on or near the annulus on an inner or upstream side of the native leaflets; and
wherein the valve support is mechanically isolated from the retainer such that the cross-sectional shape of the valve support remains sufficiently stable that the prosthetic valve remains competent when the retainer is deformed in a non-circular shape by engagement with the tissue.
2 Assignments
0 Petitions
Accused Products
Abstract
A prosthetic heart valve device (100) for percutaneous replacement of a native heart valve includes an expandable retainer (110) at least partially surrounding and coupled to an inner valve support (120). The device can further include a prosthetic valve (130) coupled to the valve support. The retainer forms a donut-shaped flange (190) having an arcuate outer surface (142) for engaging tissue and an inner lumen defining a passage for blood to flow through the valve support. The retainer can include a plurality of circumferentially positioned, resiliency deformable and flexible ribs (114) which are coupled at their downstream ends 116 to the valve support 120. The flexible ribs, in one embodiment, can have a general C-shape configuration with the tips (117) of the flexible ribs and an opening (119) of the C-shape configuration oriented toward a longitudinal axis (101) of the device.
252 Citations
126 Claims
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1. A device for repair or replacement of a native heart valve, the native heart valve having an annulus and leaflets coupled to the annulus, comprising:
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a valve support having an upstream end and a downstream end extending along a longitudinal axis, the valve support having an outer surface and an inner surface, wherein the inner surface is configured to support a prosthetic valve, and wherein the valve support has a cross-sectional shape; an expandable ring-shaped retainer coupled to the upstream end of the valve support, the retainer configured to engage and seal with tissue on or near the annulus on an inner or upstream side of the native leaflets; and wherein the valve support is mechanically isolated from the retainer such that the cross-sectional shape of the valve support remains sufficiently stable that the prosthetic valve remains competent when the retainer is deformed in a non-circular shape by engagement with the tissue. - View Dependent Claims (5, 6, 7, 13, 15, 27, 37, 38, 45, 67, 68, 69, 70, 75, 76, 77, 78, 85, 92)
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2-4. -4. (canceled)
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8-12. -12. (canceled)
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14. (canceled)
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16-26. -26. (canceled)
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28-36. -36. (canceled)
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39-44. -44. (canceled)
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46-66. -66. (canceled)
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71-74. -74. (canceled)
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79-83. -83. (canceled)
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84. A method for replacement of a native mitral valve having an annulus and a plurality of leaflets, the method comprising:
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positioning a prosthetic device between the leaflets in a collapsed configuration; allowing the prosthetic device to expand such that a retainer of the prosthetic device is in a subannular position between the native leaflets in which it engages tissue on or downstream of the annulus, wherein the retainer forms a ring having a diameter larger than a corresponding diameter of the annulus in the subannular position; and allowing a valve support to expand, the valve support being coupled to the retainer at an upstream end of the valve support; wherein the valve support is mechanically isolated from the retainer such that radial deformation of the retainer when engaging the tissue does not substantially deform the valve support. - View Dependent Claims (86, 87, 88, 126)
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89. A method of treating a mitral valve of a patient, the mitral valve having an annulus and leaflets, the method comprising:
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implanting a device within or adjacent to the annulus, the device comprising a valve support and a deformable ring-shaped retainer coupled to an upstream end of the valve support, wherein at least the retainer is disposed between the leaflets, and wherein the retainer is configured to engage and seal with tissue on or near the annulus to prevent migration of the device in an upstream direction; and wherein the valve support is mechanically isolated from the retainer such that a cross-sectional shape of the valve support does not substantially change if the retainer is radially deformed by engagement with the tissue. - View Dependent Claims (90, 91, 93, 94, 95, 96)
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97-102. -102. (canceled)
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103. A prosthetic heart valve device for treating a mitral valve, comprising:
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a valve support configured to support a valve; a ring-shaped retainer coupled to the valve support at an upstream end of the device, wherein the retainer is positionable between the native valve leaflets at least partially along a subannular surface of a native mitral valve annulus, and wherein the retainer is configured to form a fluid seal with heart tissue and to inhibit upstream migration of the device; and wherein the retainer is coupled to the valve support so as to mechanically isolate the valve support from distorting force exerted on the retainer by native anatomy. - View Dependent Claims (104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114)
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115. A prosthetic heart valve device for treating a mitral valve, comprising:
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a flexible ring-shaped retainer configured to be positioned between the native valve leaflets and to engage cardiac tissue at or downstream of a native mitral valve annulus so as to inhibit movement of the prosthetic heart valve device and to create a seal with the cardiac tissue; and an expandable valve support coupled to and extending in a downstream direction from the expandable retainer, wherein the valve support is configured to contain a prosthetic valve having a plurality of leaflets, the valve support having a deployed shape in an expanded state in which the leaflets of the prosthetic valve seal with one another; and wherein the expandable retainer is configured to flex radially to adapt to a non-circular shape of the native mitral valve annulus and the valve support remains in the deployed shape after the expandable retainer has adapted to the non-circular shape. - View Dependent Claims (116, 117, 118, 119, 120, 121, 122, 123, 124, 125)
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Specification