PERIODONTAL DISEASE TREATMENT

• US 20150352023A1
• Filed: 01/24/2014
• Published: 12/10/2015
• Est. Priority Date: 01/30/2013
• Status: Abandoned Application

• Current Assignee: Straumann Holding AG
• Original Assignee: Straumann Holding AG
• Inventors: Berg, Marianne, Raeber, George
• Application Number:
  US14/762,000
• Publication Number:
  US 20150352023A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61C 17/20 using ultrasonics
• CPC Class Codes: A61C 19/06 Implements for therapeutic treatment radiation therapy A61N5/00
• CPC Class Codes: A61C 3/02 Tooth drilling or cutting instruments; Instruments acting like a sandblast machine
• CPC Class Codes: A61C 3/06 Tooth grinding or polishing discs; Holders therefor prophylactic cups A61C17/005
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/884 Sequential application
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 33/20 Elemental chlorine; Inorganic compounds releasing chlorine
• CPC Class Codes: A61K 8/20 Halogens; Compounds thereof
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The present invention for the first time discloses a method and a kit of parts for treating a periodontal disease, such as periimplantitis, gingivitis, periodontitis and/or periimplant mucositis, caused by microorganisms that colonize a tooth and/or implant surface at, above and/or below the gingival margin, and which reside in a biofilm either subgingival and/or supragingival, characterized by employing a surgical process leading to substantively removing, destroying, killing and/or disrupting and/or inhibiting growth and/or regrowth of a pathogenic biofilm at a site of a microbial infection in a patient suffering from a periodontal disease. Said method comprises, and said kit of parts comprises the means for; cleaning disinfecting and/or debriding the site of microbial infection mechanically and sequentially using first at least one cleaning and/or disinfecting agent with an immediate bactericidal effect, such as a NaClO solution, and thereafter at least one cleaning and/or disinfecting agent with a sustainable bactericidal effect, such as a CHX solution.

Claims

5-1. A kit of parts according to claim 1, wherein said kit of parts comprises at least one further cleaning and/or disinfecting agent, which is to be administered before, after and/or together with the sodium hypochlorite (NaClO) solution and/or the chlorhexidine (CHX) solution.

9-14. -14. (canceled)

15. A sequential release formulation for treating a periodontal disease, selected from the group consisting of periimplantitis, gingivitis, periodontitis and periimplant mucositis, in a patient suffering from a periodontal disease, comprising at least two cleaning agents selected from:

a) a 0.01 to 1 weight % sodium hypochlorite (NaClO) solution and

b) a 0.01 to 1 weight %, chlorhexidine (CHX) solution,

wherein said agents are released in a given sequential order of first a) and thereafter b).

16. A formulation according to claim 15, wherein the NaClO solution has a concentration of 0.1 weight %, and the CHX solution has a concentration of 0.2 weight %.

17. A method for treating a periodontal disease, selected from the group consisting of periimplantitis, gingivitis, periodontitis and periimplant mucositis, in a patient suffering from a periodontal disease, comprising the following steps:

a) cleaning and/or disinfecting a site of microbial infection with a sodium hypochlorite (NaClO) solution; and

thereafter

b) cleaning and/or disinfecting the site of microbial infection with a chlorhexidine (CHX) solution.

2. A kit of parts according to claim 1, wherein the NaClO solution has a concentration of 0.1 weight % and the CHX solution has a concentration of 0.2 weight %.

18. The method of claim 17, further comprising a step of mechanically debriding said site of microbial infection.

19. The method of claim 18, wherein said mechanical debridement is carried out with a titanium-bristled brush.

20. The method of claim 17, further comprising the step c) wherein the site of microbial infection in a patient suffering from periimplantitis is cleaned and/or disinfected with one or more additional cleaning agent(s).

24. The method of claim 17, wherein the NaClO solution has a concentration of from 0.01 to 6 weight %, and the CHX solution has a concentration of from 0.01 to 2 weight %.

25. The method of claim 24, wherein the NaClO solution has a concentration of from 0.01 to 3 weight %, and the CHX solution has a concentration of from 0.01 to 2 weight %, such as 0.2 weight %.

19-2. The method of claim 17, further comprising, either during or before step a), the additional step of surgically assessing the site of microbial infection in and/or surrounding a tooth or dental implant.

21. The method for treating a periodontal disease, selected from the group consisting of periimplantitis, gingivitis, periodontitis and periimplant mucositis, in a patient suffering from a periodontal disease, comprising the following steps:

a) surgically assessing the site of microbial infection in and/or surrounding a tooth or dental implant;

b) mechanically cleaning and/or debriding the site of microbial infection;

c) cleaning and/or disinfecting the site of microbial infection with a sodium hypochlorite (NaClO) solution; and

thereafter

d) cleaning and/or disinfecting the site of microbial infection with a chloroheximidine (CHX) solution; and

wherein said site of the microbial infection is optionally rinsed before and/or during and/or after steps a), b), c) and d).

22. The method of claim 21, wherein step b) comprises mechanically cleaning and/or debriding said site of microbial infection with a mechanical cleaning and/or debridement tool selected from the group consisting of cuvette, drill, brush, ultrasonic device and spatula.

23. The method of claim 22, wherein said brush is a titanium-bristled brush.