MODULAR POINT-OF-CARE DEVICES, SYSTEMS, AND USES THEREOF
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Accused Products
Abstract
The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
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Citations
108 Claims
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1-78. -78. (canceled)
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79. A cartridge for detection of a plurality of analytes in a bodily fluid sample comprising:
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a housing comprising a plurality of locations configured to receive a unit or a tip, wherein said units are selected from a sample collection unit, reagent units, and assay units; a sample collection unit configured to receive the bodily fluid sample; a plurality of reagent units configured to contain reagents for running chemical reactions for detecting analytes; and a plurality of assay units, each assay unit comprising an assay tip configured to engage with a fluid transfer device and having an interior surface defining an interior region configured to receive at least a portion of the sample from the sample collection unit and to receive reagent from a reagent unit, each assay tip comprising; i) an opening configured to allow the transfer of fluids in and out of the assay tip; ii) a clear and transparent portion configured to allow passage of an optical signal therethrough; and iii) a surface having immobilized thereon reactants for a chemical reaction that yields a detectable optical signal indicative of the presence of an analyte in the sample; wherein said assay units may be moved by said fluid transfer device effective to place fluid within said sample collection unit or within reagent units into fluid communication with said interior regions of the assay units, and wherein sample, reagents, and reactants may contact each other effective to run chemical reactions and to provide optical signals for detecting said analytes. - View Dependent Claims (80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108)
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Specification