DEVICES AND METHODS FOR REMOVAL OF ACUTE BLOCKAGES FROM BLOOD VESSELS

• US 20150359547A1
• Filed: 06/11/2015
• Published: 12/17/2015
• Est. Priority Date: 06/13/2014
• Status: Active Grant

• Current Assignee: Neuravi Limited (Johnson & Johnson)
• Original Assignee: Neuravi Limited (Johnson & Johnson)
• Inventors: VALE, David, CASEY, Brendan, GILVARRY, Michael, HARDIMAN, David, MCARDLE, Kevin, HOLIAN, Maeve, KEANE, Alan, KING, Daniel
• Granted Patent: US 10,441,301 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/22032 having inflatable gripping elements balloon catheters A61M25/10
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 2017/00778 Operations on blood vessels A61B2017/22097, A61B2017/320741 take precedence
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61B 2017/22067 Blocking; Occlusion A61B2017/22054 takes precedence
• CPC Class Codes: A61B 2017/22079 with suction of debris
• CPC Class Codes: A61B 2017/2215 having an open distal end
• CPC Class Codes: A61B 2017/3435 using everted sleeves
• CPC Class Codes: A61M 1/74 Suction control underwater drainage A61M1/61
• CPC Class Codes: A61M 1/84 Drainage tubes; Aspiration tips for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32
• CPC Class Codes: A61M 2210/12 Blood circulatory system
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool

Abstract

A rapid exchange (RX) catheter may provide a proximal seal against a guide catheter inner lumen so that aspiration may be applied through a guide catheter. The catheter may include an exit port that defines a transfer port for aspiration and may enable minimal frictional engagement with the guide catheter proximal of the exit port. Aspiration can be applied to the lumen of the guide catheter and may be directed to and effective at the tip of the RX aspiration catheter. A tip of the RX catheter may facilitate aspiration and retrieval of the clot by expanding under load and can also partially or fully occlude the vessel.

Claims

1. A catheter for assisting in the retrieval of a clot from a vessel comprising a distal end and a proximal end, a distal segment and a proximal segment and a lumen extending proximal of the distal end and terminating at a transfer port at the proximal end of the distal segment and a flow restrictor located on the outer surface of the catheter distal of the transfer port.

2. A catheter as claimed in claim 1 wherein the flow restrictor is actuatable between engaged and disengaged configuration.

3. A catheter as claimed in claim 2 comprising an actuator for selectively engaging and/or disengaging the flow restrictor.

4. A catheter as claimed in claim 2 wherein the flow restrictor comprises a framework and a membrane coupled to the framework, the framework being movable by the actuator between an expanded configuration and a retracted configuration.

5. A catheter as claimed in claim 1 comprising a proximal flow restrictor distal of the proximal end of the distal segment and a distal flow restrictor spaced distally from the proximal flow restrictor.

6. A catheter as claimed in claim 1 wherein the distal end of the catheter comprises a mouth for reception of clot.

7. A catheter as claimed in claim 6 wherein the mouth is defined by an expansile tip.

8. A catheter as claimed in claim 6 wherein the distal segment includes a hinge adjacent to the distal mouth.

9. A catheter as claimed in claim 8 wherein the hinge is defined by a region of the distal segment which is configured to have lateral flexibility.

10. A catheter as claimed in claim 6 wherein the mouth has an expanded configuration and a retracted configuration.

11. A catheter as claimed in claim 10 comprising a control member for controlling the movement of the mouth between the expanded and retracted configurations.

12. A catheter as claimed in claim 11 wherein the mouth comprises a number of segments and the control member is configured to move at least some of the segments.

13. A catheter as claimed in claim 12 wherein the control member comprises a drawstring.

23. A catheter as claimed in claim 1 wherein the catheter is an aspiration catheter for aspirating a clot.

14. A catheter for aspirating a clot in a vessel comprising a distal end and a proximal end, a distal segment and a proximal segment and a lumen extending proximal of the distal end and terminating at a transfer port at the proximal end of the distal segment wherein the distal end of the catheter comprises a mouth for reception of clot.

15. A catheter as claimed in claim 14 having a flow restrictor located on the outer surface of the catheter distal of the transfer port.

16. A catheter as claimed in claim 15 wherein the mouth is defined by an expansile tip.

17. A catheter as claimed in claim 15 wherein the distal segment includes a hinge adjacent to the distal mouth.

18. A catheter as claimed in claim 17 wherein the hinge is defined by a region of the distal segment which is configured to have lateral flexibility.

19. A catheter as claimed in claim 15 wherein the mouth has an expanded configuration and a retracted configuration.

20. A catheter as claimed in claim 19 comprising a control member for controlling the movement of the mouth between the expanded and retracted configurations.

21. A catheter as claimed in claim 20 wherein the mouth comprises a number of segments and the control member is configured to move at least some of the segments.

22. A catheter as claimed in claim 21 wherein the control member comprises a draw string.

24. A system for treating an occlusion in a vessel the system comprising:

a first catheter and a second catheter;

the first catheter comprising a proximal end, a distal end and a lumen extending between the proximal end and the distal end, the lumen of the first catheter further comprising a proximal segment and a distal segment;

the second catheter comprising a distal end and a proximal end, a distal segment and a proximal segment, and a lumen, said lumen extending proximal of the distal end and terminating at a transfer port at the proximal end of the distal segment;

the first catheter being configured to facilitate aspiration through the lumen;

the transfer port being configured to transmit aspiration in the proximal lumen of the first catheter into the lumen of the distal segment of the second catheter and the distal end of the second catheter being configured to receive clot into at least a portion of the lumen of the second catheter.

25-38. -38. (canceled)

39. A method of removing a clot from a vessel, the method comprising:

providing a guide catheter and an intermediate catheter, the intermediate catheter having a distal mouth and being configured such that it is advancable within the lumen of the guide catheter;

inserting the guide catheter into a first vessel proximal of an occlusion;

advancing the intermediate catheter through the lumen of the guide catheter until the tip of the intermediate catheter extends distal of the guide catheter into a second vessel adjacent to the occlusion;

applying aspiration to the proximal end of the guide catheter;

the intermediate catheter being configured to direct said aspiration through the distal lumen of the intermediate catheter to aspirate the clot into the mouth of said intermediate catheter.

40-49. -49. (canceled)