OPTOGENETIC THERAPIES FOR MOVEMENT DISORDERS
First Claim
1. A system for controllably managing motor function in the central nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising:
- a. a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure;
b. a light source configured to provide light to the light delivery element; and
c. a controller operatively coupled to light source;
wherein the targeted tissue structure is a portion of the basal ganglia of the patient; and
wherein the controller is configured to be automatically operated to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation.
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Accused Products
Abstract
One embodiment is directed to a system for controllably managing motor function in the central nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure; a light source configured to provide light to the light delivery element; and a controller operatively coupled to light source; wherein the targeted tissue structure is a portion of the basal ganglia of the patient; and wherein the controller is configured to be automatically operated to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation.
15 Citations
22 Claims
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1. A system for controllably managing motor function in the central nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising:
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a. a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure; b. a light source configured to provide light to the light delivery element; and c. a controller operatively coupled to light source; wherein the targeted tissue structure is a portion of the basal ganglia of the patient; and
wherein the controller is configured to be automatically operated to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification