ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH SOLUBLE ACIDIC MATERIAL COATING
4 Assignments
0 Petitions
Accused Products
Abstract
An electrochemical-based analytical test strip (EBATS) for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes an electrically insulating base layer (110), a patterned electrically conductive layer (120) disposed on the electrically insulating base layer, an enzymatic reagent layer (140) disposed on the patterned electrically conductor layer, a patterned spacer layer (150), a top layer (170) having an underside surface, and a soluble acidic material coating (160) on the underside surface of the top layer. The patterned spacer layer and top layer define a sample-receiving chamber (180) within the EBATS and the soluble acidic material coating is disposed on the underside surface of the top layer within the sample-receiving chamber. In addition, the soluble acidic material coating is operably dissolvable in the bodily fluid sample such that a pH of the bodily fluid sample in the sample-receiving chamber is reduced during use of the EBATS.
-
Citations
58 Claims
-
1-29. -29. (canceled)
-
30. An electrochemical-based analytical test strip for the determination of an analyte in a bodily fluid sample, the electrochemical-based analytical test strip comprising:
-
an electrically insulating base layer; a patterned electrically conductive layer disposed on the electrically insulating base layer; an enzymatic reagent layer disposed on at least a portion of the patterned electrically conductor layer; a patterned spacer layer; a top layer having an underside surface; and a soluble acidic material coating on the underside surface of the top layer; wherein at least the patterned spacer layer and top layer define a sample-receiving chamber within the electrochemical-based analytical test strip; and wherein the soluble acidic material coating is disposed on the underside surface of the top layer within at least a portion the sample-receiving chamber; and wherein the soluble acidic material coating is operably dissolvable in the bodily fluid sample such that a pH of the bodily fluid sample in the sample-receiving chamber is reduced during use of the electrochemical-based analytical test strip. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
-
-
45. A method for determining an analyte in a bodily fluid sample, the method comprising:
-
introducing a bodily fluid sample into a sample-receiving chamber of an electrochemical-based analytical test strip, the electrochemical-based analytical test strip including; a top layer with an underside surface; and a soluble acidic material coating on the underside surface within at least a portion the sample-receiving chamber, and wherein the introduction is such that the soluble acidic material coating operably dissolves in the bodily fluid sample and reduces a pH of the bodily fluid sample in the sample-receiving chamber; detecting an electrochemical response of the electrochemical-based analytical test strip; and determining an analyte in the bodily fluid sample based on the detected analytical response. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 58)
-
-
57. The method of clam 56 wherein a thickness of the soluble acidic material coating is in the range of 5.8 microns to 17.3 microns.
Specification