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Systems and Methods for Single Cell Culture and Analysis by Microscopy and Maldi Mass Spectrometry

  • US 20150364307A1
  • Filed: 06/16/2015
  • Published: 12/17/2015
  • Est. Priority Date: 06/16/2014
  • Status: Active Grant
First Claim
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1. An isolated cell analysis device comprising a substrate having a first surface comprising a plurality of wells,the first surface comprising the plurality of wells configured to receive a suspension comprising a plurality of cells,the plurality of wells configured to have at least 25% of the wells contain one and only one cell upon receiving the suspension comprising a plurality of cells, waiting a length of time to allow the plurality of cells to settle, and removing an excess of the suspension from the first surface,each of the plurality of wells configured to allow an isolated cell contained within one of the plurality of wells to be optically interrogated and to subsequently have molecules of the isolated cell be ionized by matrix assisted laser desorption ionization via a laser impinging on the isolated cell at an angle between 5 and 85 degrees relative to the first surface.

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