TOPICAL USE OF A SKIN-COMMENSAL PREBIOTIC AGENT AND COMPOSITIONS CONTAINING THE SAME

• US 20150374607A1
• Filed: 02/12/2013
• Published: 12/31/2015
• Est. Priority Date: 02/14/2012
• Status: Abandoned Application

• Current Assignee: The Procter & Gamble Company
• Original Assignee: The Procter & Gamble Company
• Inventors: LANZALACO, Anthony Charles, CHARBONNEAU, Duane Larry, HOWARD, Brian Wilson
• Application Number:
  US14/378,943
• Publication Number:
  US 20150374607A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/60 Sugars; Derivatives thereof
• CPC Class Codes: A61K 8/604 Alkylpolyglycosides; Derivatives thereof, e.g. esters
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61K 8/737 Galactomannans, e.g. guar; Derivatives thereof
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 Liliopsida [monocotyledons]
• CPC Class Codes: A61Q 17/00 Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 Preparations for dry skin
• CPC Class Codes: A61Q 19/008 Preparations for oily skin
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: A61Q 9/02 Shaving preparations
• CPC Class Codes: C12Q 1/025 for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics antimicrobial activity C12Q1/18

Abstract

A topical cosmetic composition that includes a dermatologically acceptable carrier and an effective amount of a skin commensal prebiotic to improve the health of the skin microbiome, thereby potentially improving the condition and/or appearance of the skin. The topical cosmetic compositions may be made by identifying a potential skin commensal prebiotic agent using a first in vitro assay; confirming the prebiotic potential of an identified prebiotic agent with a second in vitro assay or an in vivo assay; and mixing a confirmed prebiotic agent from and a dermatologically acceptable carrier to form a topical cosmetic composition.

Claims

1. A topical cosmetic composition comprising:

a. a dermatologically acceptable carrier; and

b. an effective amount of a skin commensal prebiotic.

2. The composition of claim 1, wherein applying the composition to skin increases bacterial counts of at least one of an aerobic and anaerobic skin commensal microorganism in vivo according to the Plate Count Test.

3. The composition of claim 2, wherein the increase is at least 10%.

4. The composition of claim 1, wherein the skin commensal prebiotic is present in an amount of from about 0.001% to about 25% by weight of the composition.

5. The composition of claim 1, wherein the skin commensal prebiotic is present at an amount sufficient to provide an increase in ATP level of at least one skin commensal microorganism in vitro according to the ATP Test.

6. The composition of claim 5, wherein the increase is at least 80%.

7. The composition of claim 1, wherein the skin commensal prebiotic is present at an amount sufficient to provide an increase in ATP level of at least two skin commensal microorganisms in vitro.

8. The composition of claim 7, wherein the increase is at least 50%.

9. The composition of claim 1, wherein the skin commensal prebiotic is present at an amount sufficient to provide an increase in ATP level of at least three skin commensal microorganisms in vitro.

10. The composition of claim 9, wherein the increase is at least 25%.

11. The composition of claim 1, wherein the skin commensal prebiotic is present at an amount sufficient to provide an increase in bacterial counts of at least one skin commensal microorganism in vitro, according to the Plate Count Test.

12. The cosmetic composition of claim 1, wherein the skin commensal microorganism is a species selected from the group consisting of Staphylococcus genus, Corynebacterium genus, Propionibacterium genus.

13. The cosmetic composition of claim 1, wherein the skin commensal prebiotic is selected from the group consisting of galactooligosaccharide, hydroxyisoleucine, wheat dextrin, arabinogalactan, citrus fiber, pea fiber, maltodextrin, fructooligosaccharides, inulin, inulin oligofiber, mannan hydrolysates, glucomannan hydrolysates, galactomannan, gentiooligosaccharides, isomaltooligosaccharide, kiwi derived compounds, beet pulp, and rice bran.

14. The topical cosmetic composition of claim 1, further comprising at least one of a skin care active, a colorant, a moisturizer, a humectant, an emollient, a film former, a viscosity modifier, a pH buffering agent, a perfume, and a sunscreen agent.

15. The topical cosmetic composition of claim 1, wherein the composition is in the form of an emulsion.

16. The topical cosmetic composition of claim 1, wherein the composition is shave prep composition.

17. A method of making a topical cosmetic composition, comprising:

a. identifying a potential skin commensal prebiotic agent using a first in vitro assay;

b. confirming the prebiotic potential of the identified agent in (a) using at least one of a second in vitro assay and an in vivo assay;

c. mixing an effective amount of a confirmed prebiotic agent from (b) and a dermatologically acceptable carrier to form a topical cosmetic composition.

18. The method of claim 17, wherein the first in vitro assay includes measuring bacterial adenosine triphosphase level.

19. The method of claim 18, wherein the second in vitro assay includes measuring bacterial counts.

20. The method of claim 19, wherein the in vivo assay includes measuring the bacterial counts of samples collected from the skin of a person.