Hybrid Device for On-Chip Concentration, Manipulation, Sorting and Sensing of Particles on a Plasmonic Substrate

• US 20150380120A1
• Filed: 06/06/2015
• Published: 12/31/2015
• Est. Priority Date: 06/05/2014
• Status: Active Grant

• Current Assignee: Purdue Research Foundation (Purdue University)
• Original Assignee: Purdue Research Foundation (Purdue University)
• Inventors: Boltasseva, Alexandra, Wereley, Steven, Nnanna, Agbai A., Ndukaife, Justus C.
• Granted Patent: US 9,443,632 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: G02B 21/32 Micromanipulators structurally combined with microscopes
• CPC Class Codes: G02B 5/008 Surface plasmon devices diffractive gratings with a pitch less than or comparable to the wavelength G02B5/1809; surface plasmons in integrated optics G02B6/1226; optical analysis of materials by means of surface plasmons G01N21/553
• CPC Class Codes: G21K 1/006 Manipulation of neutral particles by using radiation pressure, e.g. optical levitation production or acceleration of neutral particles H05H3/00

Abstract

The present disclosure relates generally to plasmonic substrates and specifically to high-throughput trapping of particles on a plasmonic substrate.

Claims

1. A hybrid device for on-chip concentration of particles on a plasmonic substrate, comprising:

a first substrate with a bottom portion coupled to a bottom portion of a microfluidic chamber that includes a fluidic medium, wherein the fluidic medium is configured to transport a plurality of particles located in the fluidic medium when an electrothermal force is generated within the fluidic medium;

a second substrate with a bottom portion coupled to a top portion of the first substrate opposing the bottom portion of the first substrate that is non-uniform to generate a thermal gradient, wherein the thermal gradient is configured to generate the electrothermal force within the fluidic medium; and

a third substrate with a bottom portion coupled to a top portion of the second substrate opposing the bottom portion of the second substrate and a top portion that includes an electrode that is configured to receive a laser beam that heats the electrode, wherein the heated electrode generates the thermal gradient in the second substrate that generates the electrothermal force within the fluidic medium to direct particles onto the plasmonic substrate.

2. The hybrid device of claim 1, wherein the non-uniformity of the second substrate is generated from a plurality of nanoparticles included in the second substrate.

3. The hybrid device of claim 2, wherein the second substrate is excited to a resonant frequency light from the laser beam to resonate the nanoparticles included in the second substrate, wherein the resonant excitation of the plasmonic nanoparticles absorb power which is converted to heat to generate the thermal gradient.

4. The hybrid device of claim 3, wherein the resonating nanoparticles are triggered into resonance by the laser beam that heats the electrode.

5. The hybrid device of claim 4, wherein the resonating nanoparticles are triggered into resonance by rapid electrokinetic patterning (REP).

6. The hybrid device of claim 1, wherein the particles are suspended in the fluidic medium until the electrothermal force propels the particles through the fluidic medium and onto the plasmonic substrate.

7. The hybrid device of claim 1, further comprising:

a plurality of electrically conducting elements coupled to the top portion of the first substrate and the bottom portion of the third substrate and configured to conduct an alternating current (AC) electric field generated by a function generator to generate the electrothermal force included in the fluidic medium.

8. The hybrid device of claim 1, wherein a portion of the particles are propelled towards the plasmonic substrate when frequencies of the AC electric field are less than a critical frequency associated with the portion of the particles, wherein the critical frequency is the frequency that excites the portion of the particles so that the portion of the particles are trapped on the plasmonic substrate.

9. The hybrid device of claim 1, wherein the laser beam is configured to generate a Gaussian profile for the thermal gradient so that the thermal gradient is concentrated on selective portions of the third substrate.

10. The hybrid device of claim 1, wherein the selective portions of the third substrate are selected due to a lack of particles being directed to the selective portions of the first substrate as compared to other portions of the first substrate that have received sufficient particles.

11. A method for on-chip concentration of particles on a plasmonic substrate, comprising:

(i) coupling a bottom portion of a first substrate to a bottom portion of a fluidic chamber that includes a fluidic medium;

(ii) transporting a plurality of particles located in the fluidic medium when an electrothermal force is generated within the fluidic medium;

(iii) coupling a bottom portion of a second substrate to a top portion of the first substrate opposing the bottom portion of the first substrate that is non-uniform to generate a thermal gradient;

(iv) generating the thermal gradient to generate the electrothermal force within the fluidic medium;

(v) coupling a bottom portion of a third substrate to a top portion of the second substrate opposing the bottom portion of the second substrate, wherein a top portion of the third substrate includes an electrode;

(vi) receiving a laser beam by the top portion of the third substrate that includes the electrode; and

(vii) generating the thermal gradient in the second substrate from the heated electrode that generates the electrothermal force within the fluidic medium to direct particles onto the plasmonic substrate.

12. The method of claim 11, wherein the non-uniformity of the second substrate is generated from a plurality of nanoparticles included in the second substrate.

13. The method of claim 12, further comprising:

(viii) exciting the second substrate to a resonant frequency by light from the laser beam to resonate the nanoparticles included in the second substrate, wherein the resonant excition of the plasmonic nanoparticles absorb power which is converted to heat to generate the thermal gradient.

14. The method of claim 13, wherein the resonating nanoparticles are triggered into resonance by the laser beam that heats the electrode.

15. The method of claim 14, wherein the resonating nanoparticles are triggered into resonance by rapid electrokinetic patterning (REP).

16. The method of claim 11, wherein the particles are suspended in the fluidic medium until the electrothermal force propels the particles through the fluidic medium and onto the plasmonic substrate.

17. The method of claim 11, further comprising:

(ix) coupling a plurality of electrically conducting elements to the top portion of the first substrate and the bottom portion of the third substrate; and

(x) conducting an alternating current (AC) electric field generated through the plurality of electrically conducting elements from a function generator to generate the electrothermal force included in the fluidic medium.

18. The method of claim 11, further comprising:

(xi) propelling a portion of the particles towards the plasmonic substrate when frequencies of the AC electric field are less than a critical frequency associated with the portion of the particles, wherein the critical frequency is the frequency that excites the portion of the particles so that the portion of the particles are trapped on the plasmonic substrate.

19. The method of claim 11, further comprising:

(xii) generating a Gaussian profile from the thermal gradient so that the thermal gradient is concentrated on a plurality of selective portions of the third substrate.

20. The method of claim 11, further comprising:

(xiii) selecting the plurality of selective portions of the third substrate is selected due to a lack of particles being directed to the selective portions of the third substrate as compared to other portions of the third substrate that have received a sufficient quantity of particles.