INTRAVASCULAR PRESSURE DROP DERIVED ARTERIAL STIFFNESS AND REDUCTION OF COMMON MODE PRESSURE EFFECT
First Claim
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1. A system for measuring stiffness of a body lumen comprising:
- a probe including two measuring locations;
a pressure gauge, that generates a signal indicative of the differential pressure between said measurement locations; and
a controller, adapted to compute a pressure drop between said measuring locations based on the signal of the pressure gauge, for each of at least two different flow conditions, and to find a relative stiffness of the body lumen from the pressure drops.
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Abstract
In some embodiments, a method and/or device are disclosed for measuring a pressure drop over a portion of a body lumen. Optionally, the pressure drop for two different flow conditions may be used to find the stiffness of the lumen. In some embodiments the device may be calibrated, for example by correcting for distortion, for example the common mode pressure distortion. Pressure drop and or stiffness measures may be used to evaluate a treatment procedure and/or a stenosis.
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Citations
51 Claims
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1. A system for measuring stiffness of a body lumen comprising:
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a probe including two measuring locations; a pressure gauge, that generates a signal indicative of the differential pressure between said measurement locations; and a controller, adapted to compute a pressure drop between said measuring locations based on the signal of the pressure gauge, for each of at least two different flow conditions, and to find a relative stiffness of the body lumen from the pressure drops. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of measuring stiffness of a blood vessel in a subject, the method comprising:
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measuring a pressure drop across substantially the same portion of the blood vessel, for each of at least two different flow conditions; and analyzing the measured pressure drops to determine a relative stiffness of the blood vessel. - View Dependent Claims (18, 21, 23, 26, 29, 42, 43, 45)
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16-17. -17. (canceled)
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19-20. -20. (canceled)
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22. (canceled)
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24-25. -25. (canceled)
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27-28. -28. (canceled)
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30-34. -34. (canceled)
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35. The system of claim 130, wherein said controller is adapted to compute a Fractional Flow Reserve indicator.
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36-41. -41. (canceled)
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44. (canceled)
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46-49. -49. (canceled)
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50. A compound device for measuring a pressure drop in a body lumen in-vivo comprising:
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a probe of a pressure drop between two sensing locations; a sleeve that surrounds the pressure-measuring probe when it is inserted into the blood vessel, the pressure-measuring catheter being adapted to withdraw into and extend out of the sleeve; a sensor generate a signal indicative the pressure drop between said sensing locations; and a controller adapted to discern a distortion of said signal generated when the probe is surrounded by the sleeve.
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51-53. -53. (canceled)
Specification