METHOD AND SYSTEMS FOR ADJUSTING AN IMAGING PROTOCOL

• US 20160000401A1
• Filed: 07/07/2014
• Published: 01/07/2016
• Est. Priority Date: 07/07/2014
• Status: Abandoned Application

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Mienkina, Martin
• Application Number:
  US14/325,137
• Publication Number:
  US 20160000401A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 8/0866 involving foetal diagnosis; pre-natal or peri-natal diagnosis of the baby
• CPC Class Codes: A61B 8/14 Echo-tomography
• CPC Class Codes: A61B 8/463 characterised by displaying multiple images or images and diagnostic data on one display composite display in devices for short-range imaging with acoustic waves G01S7/52074
• CPC Class Codes: A61B 8/5223 for extracting a diagnostic or physiological parameter from medical diagnostic data for algorithms to analyse biomedical images G06T7/0012
• CPC Class Codes: A61B 8/54 Control of the diagnostic device
• CPC Class Codes: A61B 8/565 involving data transmission via a network
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

Various methods and systems are provided for imaging a fetus. One example method for imaging a fetus includes obtaining genetic analysis information of the fetus, and adjusting an ultrasound image acquisition protocol based on the information.

Claims

1. A method for imaging a fetus, comprising:

obtaining genetic analysis information of the fetus; and

adjusting an ultrasound image acquisition protocol based on the information.

2. The method of claim 1, wherein the ultrasound image acquisition protocol comprises a list of diagnostic parameters to be obtained during ultrasound imaging of the fetus, the diagnostic parameters comprising one or more of imaged anatomical structures and measured anatomical features.

3. The method of claim 2, wherein adjusting the ultrasound image acquisition protocol based on the information comprises adjusting which anatomical structures of the fetus are imaged based on the information.

4. The method of claim 2, wherein adjusting the ultrasound image acquisition protocol based on the information comprises adjusting which anatomical features of the fetus are measured based on the information.

5. The method of claim 2, wherein the ultrasound image acquisition protocol further comprises a determination of a characteristic of the fetus based on a comparison of one or more measured anatomical features of the fetus to a population curve, and wherein adjusting the ultrasound image acquisition protocol based on the information further comprises adjusting the population curve based on the information.

6. The method of claim 2, wherein the genetic analysis information comprises a probability of the fetus having a given genetic disorder, and wherein adjusting the ultrasound image acquisition protocol based on the information comprises:

if the probability is above a threshold, adjusting the ultrasound image acquisition protocol to include a first set of diagnostic parameters; and

if the probability is below the threshold, adjusting the ultrasound image acquisition protocol to include a second set of diagnostic parameters, different than the first set.

7. The method of claim 6, further comprising obtaining a plurality of images of anatomical structures of the fetus and a plurality of measurements of anatomical features of the fetus following the adjusted ultrasound image acquisition protocol, and generating one or more of an updated probability of the fetus having the genetic disorder and a severity assessment of the genetic disorder based on the plurality of images and the plurality of measurements.

8. The method of claim 1, wherein obtaining the genetic analysis information comprises obtaining the information from a remote server, and wherein the genetic analysis comprises a DNA analysis of the fetus performed on fetal DNA reconstructed from a maternal blood sample.

9. The method of claim 1, wherein the genetic analysis information is indicative of a sex of the fetus, and wherein adjusting the ultrasound image acquisition protocol based on the information comprises adjusting a color of one or more rendered images of the fetus during imaging of the fetus based on the sex of the fetus.

10. The method of claim 1, wherein adjusting the ultrasound image acquisition protocol includes adjusting an order in which a plurality of images of the fetus are taken.

11. The method of claim 1, wherein adjusting the ultrasound image acquisition protocol based on the genetic information comprises adjusting one or more of ultrasound signal transmission parameters, ultrasound signal receive parameters, ultrasound signal processing parameters, or ultrasound signal display parameters.

12. A system for imaging a fetus, comprising:

an ultrasound probe to emit ultrasonic signals to a volume of the fetus;

an ultrasound receiver to receive echoes of the emitted ultrasonic signals; and

a computing system operably connected to the ultrasound probe, ultrasound receiver, and a display device, the computing system including instructions to;

obtain genetic analysis information of the fetus;

adjust an ultrasound image acquisition protocol based on the information; and

generate a user interface for display on the display device, the user interface comprising information to instruct a user to follow the adjusted ultrasound image acquisition protocol.

13. The system of claim 12, wherein the ultrasound image acquisition protocol comprises a predefined list of anatomical structures and features to be imaged and measured during imaging of the fetus, and wherein the computing system includes instructions to, during adjustment of the ultrasound image acquisition protocol, adjust which anatomical structures are imaged and which anatomical features are measured based on the information.

14. The system of claim 13, wherein the user interface further comprises a comparison of one or more of the measured anatomical features to a population curve, and wherein the population curve is adjusted based on the information.

15. The system of claim 12, wherein the computing system includes further instructions to process the received echoes into one or more images for display via the user interface, the images acquired according to the adjusted ultrasound image acquisition protocol.

16. The system of claim 12, wherein the computing system obtains raw DNA sequencing data from a remote device and determines a probability of the fetus displaying a particular phenotype based on the raw DNA sequencing data.

17. The system of claim 12, wherein the computing system obtains the information from a remote device.

18. The system of claim 12, wherein the genetic analysis information is indicative of a sex of the fetus, and wherein the computing system includes instructions to, during adjustment of the ultrasound image acquisition protocol, adjust a color of one or more rendered images of the fetus during imaging of the fetus based on the sex of the fetus.

19. A system for imaging a fetus, comprising:

an ultrasound probe to emit ultrasonic signals to a volume of the fetus;

an ultrasound receiver to receive echoes of the emitted ultrasonic signals; and

a computing system operably connected to the ultrasound probe, ultrasound receiver, and a display device, the computing system including instructions to;

obtain information indicative of a probability of the fetus having a given genetic disorder based on a DNA sequence analysis of the fetus;

select an ultrasound image acquisition protocol based on the information, the ultrasound image acquisition protocol comprising a predefined list of soft markers of the given genetic disorder to be measured;

acquire a plurality of images of the fetus according to the selected ultrasound image acquisition protocol, each image processed by the computing system from the echoes received by the ultrasound receiver;

measure the soft markers from the acquired images;

compare one or more of the measured soft markers to a respective population curve; and

determine an updated probability of the fetus having the genetic disorder and/or perform a severity assessment of the genetic disorder based on the comparison.

20. The system of claim 19, wherein the genetic disorder is trisomy 21, and wherein:

if the probability of the fetus having trisomy 21 is greater than a threshold, the selected ultrasound image acquisition protocol has a first, larger number of trisomy 21 soft markers to be measured, and

if probability the of the fetus having trisomy 21 is less than the threshold, the selected ultrasound image acquisition protocol has a second, smaller number of trisomy 21 soft markers to be imaged.