TREATMENT OF PETS WITH SIRTUIN ACTIVATORS
First Claim
1. A pet food composition comprising:
- a. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and
b. about 0.0005 to 0.05 wt % of a sirtuin activator.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides for systems, compositions, methods and kits for regulating energy metabolism in pets. The systems, compositions, and kits can comprise, and methods can make use of, pet foods, pet treats, pet supplements, and pet drinks. In one aspect, the invention provides for pet food, treat, supplement, and drink compositions that comprise a combination of (a) leucine, and (b) a sirtuin activator, or any precursors or metabolites of (a) or (b). These combinations may be effective for reducing weight or adipose volume in the pet. In another aspect, the invention provides for methods of regulating energy metabolism by the administration of one or more compositions comprising leucine, a leucine metabolite, and/or a sirtuin activator. The invention also provides for kits comprising compositions of leucine, a leucine metabolite, and/or a sirtuin activator packaged in an oral dose form with usage instructions.
-
Citations
113 Claims
-
1. A pet food composition comprising:
-
a. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and b. about 0.0005 to 0.05 wt % of a sirtuin activator. - View Dependent Claims (80, 81, 82, 83, 84, 85, 86, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113)
-
-
2. A pet food, treat or supplement composition comprising:
-
a. at least about 50 mg of leucine and/or at least about 5 mg of one or more leucine metabolites; and b. at least about 1 mg of a sirtuin activator.
-
-
3. A pet food composition comprising:
-
a. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; b. about 0.0005 to 0.05 wt % of a sirtuin activator; and c. an additional component selected from the group consisting of omega-3 fatty acid, eicosapentanoic acid, choline, manganese, methionine, cysteine, L-carnitine, lysine, alpha lipoic acid, dimethylaminoethanol, pyruvic acid, actyl L-carnitine, L-carnitine, conjugated linoleic acid, diacylglyceride, chondroitin, glucosamine, ginger (or extract thereof), chicory pulp, and myrtle. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
-
-
4. A pet food, treat or supplement composition comprising:
-
a. at least about 50 mg of leucine and/or at least about 5 mg of one or more leucine metabolites; b. at least about 1 mg of a sirtuin activator; and c. an additional component selected from the group consisting of omega-3 fatty acid, eicosapentanoic acid, choline, manganese, methionine, cysteine, L-carnitine, lysine, alpha lipoic acid, dimethylaminoethanol, pyruvic acid, actyl L-carnitine, L-carnitine, conjugated linoleic acid, diacylglyceride, chondroitin, glucosamine, ginger (or extract thereof), chicory pump, and myrtle. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
-
-
34. A pet food composition comprising:
-
a. about 0.05 to 5 wt. % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites on a dry matter basis; b. about 0.0005 to 0.05 wt. % of a sirtuin activator on a dry matter basis; c. about 26 to 35 wt. % of crude protein on a dry matter basis; d. about 7.5 to 8.5 wt. % of crude fat on a dry matter basis; e. about 20 to 30 wt. % of total dietary fiber on a dry matter basis; and f. about 10 to 20 wt. % of crude fiber on a dry matter basis.
-
-
35. A pet food composition comprising:
N pieces wherein N pieces provide the complete and balanced daily nutritional requirements of an animal, and N equals 1 to less than 15 pieces, wherein each piece has a caloric content between 50 to 2500 kcal, and wherein N pieces comprise (a) at least about 100 mg of leucine and/or at least about 10 mg of one or more leucine metabolites and (b) at least about 1 mg of a sirtuin activator.
-
36. A diet for promoting comprehensive weight management in companion animals comprising:
-
a first stage pet food composition for promoting weight loss and a second stage pet food composition for maintaining the weight loss, (a) said first stage pet food composition comprising, on a dry matter basis, about 35 to 70% by weight of a protein, about 4 to 10% by weight of a fat, about 2 to 25% by weight of a fiber, about 10 to 35% by weight of a carbohydrate, about 0.05 to 5% by weight of leucine and/or about 0.005 to 1% by weight of one or more leucine metabolites, about 0.0005 to 0.05% by weight of a sirtuin activator, and about 0.1 to 2% by weight of a functional ingredient, wherein said functional ingredient is selected from the group consisting of L-carnitine and conjugated linoleic acid; and (b) said second stage pet food composition comprising, on a dry matter basis, about 20 to 35% by weight of a protein, about 4 to 10% by weight of a fat, about 2 to 25% by weight of a fiber, about 25 to 70% by weight of a carbohydrate, and about 0.1 to 2% by weight of a functional ingredient, wherein said functional ingredient is selected from the group consisting of L-carnitine and conjugated linoleic acid, wherein the protein content of the second stage pet food composition is about 10 to 45% less than the protein content of the first stage pet food composition.
-
-
37. A pet food composition comprising:
-
a. a live probiotic microorganism; b. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and c. about 0.0005 to 0.05 wt % of A sirtuin activator. - View Dependent Claims (39, 40, 41)
-
-
38. A pet food composition comprising:
-
a. a live probiotic microorganism; b. at least about 50 mg of leucine and/or at least about 5 mg of one or more leucine metabolites by weight of the pet food composition; and c. at least about 1 mg of a sirtuin activator by weight of the pet food composition.
-
-
42. A pet food compositions comprising:
-
a. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; b. about 0.0005 to 0.05 wt % of a sirtuin activator; and c. a pre-selected balance of metabolizable cations to metabolizable anions, wherein the DCAB is between about 50 to 300.
-
-
43. A method for treating a puppy susceptible to or suffering from diarrhea and/or loose stool comprising:
-
a. feeding the puppy a food composition comprising (i) about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites and (ii) about 0.0005 to 0.05 wt % of a sirtuin activator; and b. adjusting the balance of metabolizable cations to metabolizable anions consumed by the puppy by an amount sufficient to improve stool quality by increasing the balance of metabolizable cations to metabolizable anions consumed by the puppy to produce firmer stool.
-
-
44. A pet food composition for reducing odor of stool of a companion animal comprising:
-
a. stool odor-reducing effective amount of ginger or an extract thereof; b. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and c. about 0.0005 to 0.05 wt % of a sirtuin activator. - View Dependent Claims (45, 46)
-
-
47. A method for reducing odor of stool of a companion animal, the method comprising causing the animal to ingest a pet food composition comprising:
-
a. a stool odor-reducing effective amount of ginger or an extract thereof; b. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and c. about 0.0005 to 0.05 wt % of a sirtuin activator. - View Dependent Claims (48, 49)
-
-
50. A pet food composition which comprises:
-
a. chicory pulp in an amount which;
i) maintains good feces quality or improves the feces quality of a pet and/or ii) maintains good gastrointestinal tract health and/or improves the gastrointestinal tract health of a pet;b. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and c. about 0.0005 to 0.05 wt % of a sirtuin activator. - View Dependent Claims (51, 52, 53)
-
-
54. A pet food composition comprising
a. an inner layer comprising kibble; -
b. an outer layer; c. about 0.05 to 5% of leucine and/or about 0.005 to 1% of one or more leucine metabolites by weight of the pet food composition; and d. about 0.0005 to 0.05% of a sirtuin activator by weight of the pet food composition. - View Dependent Claims (55, 56)
-
-
57. A pet food or supplement composition comprising
a. an inner layer comprising kibble; -
b. an outer layer; and c. at least about 50 mg of leucine and/or at least about 5 mg of one or more leucine metabolites by weight of the pet food composition; and d. at least about 1 mg of a sirtuin activator by weight of the pet food composition. - View Dependent Claims (58, 59)
-
-
60. A pet food composition comprising:
-
a. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; b. about 0.0005 to 0.05 wt % of a sirtuin activator; and c. a palatability enhancer selected from the group consisting of butyric acid, 3-methylbutyric acid, tetrasodium pyrophosphate, 2-piperidione, 2,3 pentanedione, 2-ethyl-3,5-dimethylpyrazine, furfural, sulfurol, and indole.
-
-
61. A pet food or supplement composition comprising
a. at least about 50 mg of leucine and/or at least about 5 mg of one or more leucine metabolites by weight of the pet food composition; -
b. at least about 1 mg of a sirtuin activator by weight of the pet food composition; and c. a palatability enhancer selected from the group consisting of butyric acid, 3-methylbutyric acid, tetrasodium pyrophosphate, 2-piperidione, 2,3 pentanedione, 2-ethyl-3,5-dimethylpyrazine, furfural, sulfurol, and indole.
-
-
62. A pet food composition comprising:
-
an outer layer joined to an inner layer, wherein the outer layer is harder than the inner layer; about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and about 0.0005 to 0.05 wt % of a sirtuin activator.
-
-
63. A pet food composition comprising:
-
a structurant for providing a textured appearance and feel; about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and about 0.0005 to 0.05 wt % of a sirtuin activator.
-
-
64. A pet food composition comprising:
-
a textured layer bonded to a base layer, wherein the textured layer comprises textured components bonded to the base layer; about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and about 0.0005 to 0.05 wt % of a sirtuin activator.
-
-
65. A pet food composition comprising:
-
less than about 19% on a dry weight basis of carbohydrate; about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and about 0.0005 to 0.05 wt % of a sirtuin activator. - View Dependent Claims (66)
-
-
67. A method for feeding a pet comprising:
-
a. providing, over an extended and preselected period of time, different food compositions to said animal in which each composition provides an enriched source of fat, protein or carbohydrate, such that said animal can select and consume different and preferred quantities of each said food compositions in order to achieve an preferred consumption of fat, protein and carbohydrate for said animal; wherein at least one of said food compositions comprises about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and
about 0.0005 to 0.05 wt % of a sirtuin activator;b. allowing said animal to consume the different and preferred quantities of fat, protein and carbohydrate from each of said compositions over the extended preselected period of time; and c. determining, from the consumed amount of fat, protein and carbohydrate from each of said compositions, a customized dietary regime that provides the preferred macronutrient content of a diet for said individual animal.
-
-
68. A computer-readable medium comprising code that, upon execution by one or more processors, implements a method of producing a customized dry pet food composition formulated from a dry pet food kibble recipe and selected functional ingredients, the formulation being selected on the basis of an individual pet'"'"'s attributes and physical conditions, the method comprising:
-
a. receiving information on the individual pet'"'"'s attributes and physical conditions; b. selecting a predetermined volume of dry kibble pieces from a plurality different formulations of pre-made dry kibble pieces; c. selecting one or more functional ingredients from a plurality functional ingredients; d. coating the predetermined volume of dry kibble pieces with the one or more functional ingredients; and e. packaging and labeling the predetermined volume of coated dry kibble pieces; wherein the selection of the predetermined volume of dry kibble pieces and one or more functional ingredients is based on the individual pet'"'"'s attributes and physical conditions to provide the customized dry pet food product, and wherein the coating and/or the kibble pieces comprise leucine and/or a leucine metabolite and a sirtuin activator. - View Dependent Claims (69)
-
-
70. A method of producing a customized dry pet food product formulated from a dry pet food kibble recipe and selected functional ingredients, the formulation being selected on the basis of an individual pet'"'"'s attributes and physical conditions, the method comprising:
-
a. providing a plurality of different formulations of pre-made dry kibble pieces; b. selecting a predetermined volume of dry kibble pieces from the plurality of different formulations of pre-made dry kibble pieces; c. providing a plurality of functional ingredients; d. coating the volume of dry kibble pieces with one or more of the plurality of functional ingredients; and e. packaging and labeling the predetermined volume of coated dry kibble pieces; wherein the selection of the predetermined volume of dry kibble pieces and the one or more functional ingredients is based on the individual pet'"'"'s attributes and physical conditions to provide the customized dry pet food product, and wherein the coating and/or the kibble pieces comprise leucine and/or a leucine metabolite and a sirtuin activator. - View Dependent Claims (71)
-
-
72. A diet for companion animals comprising:
a first stage pet food composition and a second stage pet food composition for maintaining the weight loss, wherein each of said first stage pet food composition and said second stage pet food composition comprise, on a dry matter basis, about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites, and about 0.0005 to 0.05 wt % of a sirtuin activator, and wherein said second stage pet food comprises at least about 5% higher fat content compared to said first stage pet food.
-
73. A vegetarian pet food composition comprising:
-
a. a vegetarian kibble which incorporates a non-meat based flavor-enhancing additive; b. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and c. about 0.0005 to 0.05 wt % of a sirtuin activator.
-
-
74. A vegetarian pet food or supplement composition comprising:
-
a. a vegetarian kibble which incorporates a non-meat based flavor-enhancing additive; b. at least about 50 mg of leucine and/or at least about 5 mg of one or more leucine metabolites by weight of the pet food composition; and c. at least about 1 mg of a sirtuin activator by weight of the pet food composition.
-
-
75. A multi-component pet food composition comprising two or more compartmentalized food compositions, wherein the at least two compartmentalized compositions differ in their content in at least two of fat, protein or carbohydrate, and further wherein one of the two or more compartmentalized compositions comprises about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites, and about 0.0005 to 0.05 wt % of a sirtuin activator.
-
76. A pet food composition for increasing the shelf life of a physically discrete dry pet food comprising:
-
a. a coat covering the physically discrete pet food composition comprising a polymer film, wherein the film or an agent in the film protects the composition from oxidation decomposition and/or protects the composition from bacterial growth, wherein the film comprises a starch/synthetic polymer selected from the group consisting of starch/polyethylene, and starch/low-density polyethylene, and wherein the thickness of said coat is 1-2000 microns; b. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and c. about 0.0005 to 0.05 wt % of a sirtuin activator.
-
-
77. A method for increasing the shelf life of a physically discrete dry pet food composition comprising:
-
coating the physically discrete pet food composition with a polymer film, wherein the film or an agent in the film protects the composition from oxidation decomposition and/or protects the composition from bacterial growth, wherein the film comprises a starch/synthetic polymer selected from the group consisting of starch/polyethylene, and starch/low-density polyethylene, wherein the thickness of said coating is 1-2000 microns; and wherein the pet food composition comprises about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites and about 0.0005 to 0.05 wt % of a sirtuin activator.
-
-
78. A method for making kibble at one location and finishing the pet food at another location comprising:
-
a. forming a dry, stable intermediate of the pet food composition at a first location; b. finishing the dry, stable intermediate pet food composition to form a finished pet food composition at a second location remote from the first location, wherein said finished pet food composition contains about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites and about 0.0005 to 0.05 wt % of a sirtuin activator.
-
-
79. A hypoallergenic pet food composition comprising:
-
a. proteinaceous component that has been hydrolyzed whereby said component is rendered hypoallergenic to a pet, wherein said proteinaceous component is made up of polypeptides and free amino acids having an average molecular weight of less than about 3,000 Daltons; b. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and c. about 0.0005 to 0.05 wt % of a sirtuin activator.
-
-
87. A method of increasing production of irisin in a pet comprising administering to the pet a pet food, pet treat, pet snack or pet drink composition that comprises:
-
a. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and b. about 0.0005 to 0.05 wt % of a sirtuin activator, wherein the production of irisin in the pet is increased.
-
-
88. A method of increasing production of irisin in a pet comprising administering to the pet a pet food, pet treat, pet snack or pet drink composition that comprises:
-
a. at least about 50 mg of leucine and/or at least about 5 mg of one or more leucine metabolites; b. about 1 mg of a sirtuin activator, wherein the production of irisin in the pet is increased.
-
-
89. A method of increasing insulin sensitivity in a pet comprising administering to the pet a pet food, pet treat, pet snack or pet drink composition that comprises:
-
a. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and b. about 0.0005 to 0.05 wt % of a sirtuin activator, wherein the insulin sensitivity of the pet is increased.
-
-
90. A method of increasing insulin sensitivity in a pet comprising administering to the pet a pet food, pet treat, pet snack or pet drink composition that comprises:
-
a. at least about 50 mg of leucine and/or at least about 5 mg of one or more leucine metabolites; b. at least about 1 mg of a sirtuin activator, wherein the insulin sensitivity in the pet is increased.
-
-
91. A method of reducing inflammation in a pet comprising administering to the pet a pet food, pet treat, pet snack or pet drink composition that comprises:
-
a. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and b. about 0.0005 to 0.05 wt % of a sirtuin activator, wherein the inflammation in the pet is reduced.
-
-
92. A method reducing inflammation in a pet comprising administering to the pet a pet food, pet treat, pet snack or pet drink composition that comprises:
-
a. at least about 50 mg of leucine and/or at least about 5 mg of one or more leucine metabolites; and b. about 1 mg of a sirtuin activator, wherein the inflammation in the pet is reduced.
-
-
93. A method of reducing and/or preventing diabetes in a pet comprising administering a pet food, pet treat, pet snack or pet drink composition that comprises:
-
a. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and b. about 0.0005 to 0.05 wt % of a sirtuin activator, wherein the effects of diabetes in the pet are reduced or prevented.
-
-
94. A method of reducing and/or preventing diabetes in a pet comprising administering a pet food, pet treat, pet snack or pet drink composition that comprises:
-
a. at least about 50 mg of leucine and/or at least about 5 mg of one or more leucine metabolites; and b. at least about 1 mg of a sirtuin activator, wherein the effects of diabetes in the pet are reduced or prevented.
-
-
95. A pet food composition comprising:
-
a. about 0.05 to 5 wt % of leucine and/or about 0.005 to 1 wt % of one or more leucine metabolites; and b. about 0.0005 to 0.05 wt % of a sirtuin activator; and c. about 1.5 g/kg metformin, about 0.75 g/kg metformin, about 0.25 g/kg metformin.
-
-
96. A pet food, treat or supplement composition comprising:
-
a. at least about 50 mg of leucine and/or at least about 5 mg of one or more leucine metabolites; b. at least about 1 mg of a sirtuin activator; and c. at least about 125 mg metformin
-
Specification