LOW CONCENTRATION ANTIBODY FORMULATIONS
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Abstract
The present invention is directed formulations for low concentrations of therapeutic proteins and methods of making the same. In one aspect the present invention is directed to a formulation for a therapeutic protein comprising: a) the therapeutic protein; and b) a surfactant; wherein the molar ratio of surfactant to therapeutic protein is at least 100. In another aspect the present invention is directed to a formulation for a therapeutic protein comprising: a) the therapeutic protein; and b) an antioxidant, wherein the molar ratio of antioxidant to therapeutic protein is at least 750.
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Citations
42 Claims
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1-28. -28. (canceled)
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29. A formulation for a therapeutic protein comprising:
- a) the therapeutic protein; and
b) a surfactant;
wherein the molar ratio of surfactant to therapeutic protein is at least 100. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 42)
- a) the therapeutic protein; and
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40. A formulation for a therapeutic protein comprising:
- a) the therapeutic protein; and
b) 0.01% w/v to 0.5% w/v surfactant, wherein the molar ratio of surfactant to therapeutic protein is at least 100;
c) 1 mM to 50 mM antioxidant, wherein the molar ratio of antioxidant to therapeutic protein is at least 750; and
d) 1 mM to 100 mM buffer, wherein the pH of the formulation is 4.0 to 8.0. - View Dependent Claims (41)
- a) the therapeutic protein; and
Specification