NASAL DELIVERY

• US 20160001022A1
• Filed: 02/10/2015
• Published: 01/07/2016
• Est. Priority Date: 04/05/2007
• Status: Active Grant

• Current Assignee: OptiNose, Inc.
• Original Assignee: Colin David Sheldrake, Per Gisle Djupesland
• Inventors: DJUPESLAND, Per Gisle, SHELDRAKE, Colin David
• Granted Patent: US 10,076,615 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0098 Activated by exhalation
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 15/085 Fixing means therefor
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2210/0625 Mouth

Abstract

A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject, wherein the nosepiece comprises a tip element which includes a delivery aperture from which substance is in use delivered into the nasal cavity, and the tip element is at least in part tapered such as to be inclined to a longitudinal axis of the nosepiece, with the delivery aperture extending both laterally across the tip element and along a longitudinal extent of the tip element; a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity; and a delivery unit for delivering substance through the nozzle of the nosepiece.

Claims

1-81. -81. (canceled)

82. A method of fitting a nasal delivery device to a nostril of a subject, the method comprising:

inserting a nosepiece of the nasal delivery device into one of the nostrils of the subject, with the nasal delivery device having a first alignment;

twisting the nosepiece in the nostril so as to rotate the nasal delivery device to have a second alignment different from the first alignment; and

sealing a nare of the nostril against the nosepiece.

83. The method of claim 82, further comprising:

applying a grip-enhancing agent to an exterior surface of a nose of the subject.

84. The method of claim 82, wherein the nosepiece comprises a tip element.

85. The method of claim 84, wherein the tip element is substantially elliptical.

86. The method of claim 84, Wherein the tip element is substantially rectangular.

87. The method of claim 84, wherein the tip element comprises a delivery aperture.

88. The method of claim 84, wherein the tip element is tapered.

89. The method of claim 82, wherein the nasal delivery device comprises a delivery unit and a nose gripping member.

90. The method of claim 89, wherein the nose gripping member is tethered to a body of the nasal delivery device.

91. The method of claim 89, wherein the nose gripping member comprises a gripping element which is configured to be fixed to a nose of the subject.

92. The method of claim 82, further comprising:

pressing a finger against the skin of the nose so as to press the nare of the nostril against the nosepiece.

93. The method of claim 82, further comprising:

pulling the nare of the nostril over the nosepiece.

94. The method of claim 93, wherein the pulling is done by a finger.

93-1. The method of claim 82, further comprising:

exhaling through a mouthpiece.