DEVICES AND METHODS FOR OPTIMIZED NEUROMODULATION AND THEIR APPLICATION
First Claim
1. A method for neuromodulation by one or more neuromodulation modalities of one or a plurality of neural targets comprising:
- a. providing one or a plurality of neuromodulation transducers;
b. aiming the energy of said ultrasound transducers at one or a plurality of applicable neural targets; and
c. neuromodulating the ultrasound transducers with patterned stimulation selected from the group consisting of random pulse pattern, Fibonacci sequence pulsing, continuous non-pulsed, burst-pattern mode, multiple-frequency amplitude modulation, sweep amplitude modulation frequency, sweep pulse frequency, sweep duty cycle.
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Abstract
Disclosed are methods and systems for optimized deep or superficial deep-brain stimulation using multiple therapeutic modalities impacting one or multiple points in a neural circuit to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Also disclosed are methods for treatment of clinical conditions and obtaining physiological impacts. Also disclosed are: methods and systems for Guided Feedback control of non-invasive deep brain or superficial neuromodulation; patterned neuromodulation, ancillary stimulation, treatment planning, focused shaped or steered ultrasound; methods and systems using intersecting ultrasound beams; non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier; non-invasive neuromodulation of the spinal cord by ultrasound energy; methods and systems for non-invasive neuromodulation using ultrasound for evaluating the feasibility of neuromodulation treatment using non-ultrasound/ultrasound modalities; neuromodulation of the whole head, treatment of multiple conditions, and method and systems for neuromodulation using ultrasound delivered in sessions.
107 Citations
20 Claims
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1. A method for neuromodulation by one or more neuromodulation modalities of one or a plurality of neural targets comprising:
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a. providing one or a plurality of neuromodulation transducers; b. aiming the energy of said ultrasound transducers at one or a plurality of applicable neural targets; and c. neuromodulating the ultrasound transducers with patterned stimulation selected from the group consisting of random pulse pattern, Fibonacci sequence pulsing, continuous non-pulsed, burst-pattern mode, multiple-frequency amplitude modulation, sweep amplitude modulation frequency, sweep pulse frequency, sweep duty cycle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for neuromodulation by one or more neuromodulation modalities of one or a plurality of neural targets comprising:
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a. providing one or a plurality of neuromodulation transducers; b. aiming the energy of said ultrasound transducers at one or a plurality of applicable neural targets; and c. neuromodulating the ultrasound transducers using guided-feedback neuromodulation wherein a set of neuromodulation parameters/variables is applied in a given segment, the patient, operator, or agent judges the result, and based on that input an algorithm is applied to determine the neuromodulation parameters/variables to be applied in the next segment. - View Dependent Claims (14, 15, 16, 17)
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18. A method for neuromodulation by one or more neuromodulation modalities of one or a plurality of neural targets comprising:
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d. providing one or a plurality of neuromodulation transducers; e. aiming the energy of said ultrasound transducers at one or a plurality of applicable neural targets; and f. neuromodulating the ultrasound transducers combining a first modality of neuromodulation with a second modality of neuromodulation, ancillary stimulation, selected from the group consisting of visual, auditory, tactile, vibration, pain, proprioceptive stimulation, and any other form of energy input can be applied, whereby the first modality of neuromodulation selected from the group consisting of deep brain stimulation, spinal cord stimulation, vagal nerve stimulation, sphenopalatine ganglion stimulation, occipital nerve stimulation, transcranial magnetic stimulation, ultrasound neuromodulation, radiofrequency stimulation, and optogenetics. - View Dependent Claims (19, 20)
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Specification