IMAGE DETECTION SYSTEM FOR DIAGNOSING PHYSIOLOGIC STATUS OF ORGAN HAVING FLUORESCENT MATTER

• US 20160007855A1
• Filed: 02/17/2015
• Published: 01/14/2016
• Est. Priority Date: 07/09/2014
• Status: Abandoned Application

• Current Assignee: National Taiwan University (Government of The Republic of China)
• Original Assignee: National Taiwan University (Government of The Republic of China)
• Inventors: Liu, Tzu-Ming
• Application Number:
  US14/624,002
• Publication Number:
  US 20160007855A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 5/0064 Body surface scanning
• CPC Class Codes: A61B 5/0068 Confocal scanning
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61K 49/0034 Indocyanine green, i.e. ICG, cardiogreen

Abstract

An image detection system for diagnosing a metabolic function and physiological status of a tissue or an organ having a fluorescent matter is provided. The image detection system includes a source emitting exciting light, a scan unit converting the exciting light into a scan of the exciting light, a light-guiding unit including an object lens, a splitter unit, and a detection unit. The splitter unit directs the scan of the exciting light to enter a tissue having a fluorescent matter such that the fluorescent matter in the tissue is excited by the scan of the exciting light and emits fluorescence light, whereby a layer of the tissue is scanned by the scan of the exciting light. The splitter unit directs the fluorescence light emitted from the tissue to the detection unit for processing so as to generate a fluorescent image of the layer of the tissue.

Claims

1. An image detection system, comprising:

a source that emits exciting light;

a scan unit that converts the exciting light into a scan of the exciting light;

a light-guiding unit including an object lens, the object lens guiding the scan of the exciting light into a tissue having a fluorescent matter such that the fluorescent matter in the tissue is excited by the scan of the exciting light and emits fluorescence light, whereby a layer of the tissue is scanned by the scan of the exciting light;

a detection unit that detects and processes the fluorescence light emitted by the tissue, so as to generate a fluorescent image of the layer of the tissue; and

a splitter unit that directs the scan of the exciting light to the object lens so as to enter the tissue, and further directs the fluorescence light emitted by the tissue to the detection unit such that the fluorescent image of the layer of the tissue is generated by the detection unit.

2. The image detection system of claim 1, wherein the detection unit comprises a filter, a photomultiplier and a processor, the filter is used to allow the fluorescence light having a particular wavelength to enter the photomultiplier, so as for the photomultiplier to receive and convert the fluorescence light into an electric signal, and then for the processor to process the electric signal and generate the fluorescent image of the layer of the tissue.

3. The image detection system of claim 1, wherein the splitter unit reflects the scan of the exciting light to the object lens such that the scan of the exciting light enters the tissue via the object lens, and further transmits the fluorescence light emitted by the tissue to the detection unit.

4. The image detection system of claim 1, wherein the splitter unit transmits the scan of the exciting light to the tissue, and further reflects the fluorescence light emitted by the tissue to the detection unit.

5. The image detection system of claim 1, wherein the exciting light has a wavelength in a range of 400 nm-650 nm or 760 nm-800 nm.

6. The image detection system of claim 1, wherein the fluorescence light emitted by the tissue has a wavelength in a range of 820 nm-850 nm, 530 nm-550 nm or 655 nm-685 nm.

7. The image detection system of claim 1, wherein the fluorescent matter is indocyanine green, bilirubins, flavins, or bilirubin oxidants.

8. The image detection system of claim 1, wherein the object lens is an f-theta lens.

9. An image detection system, comprising:

a source that emits exciting light;

a scan unit that converts the exciting light into a scan of the exciting light;

a light-guiding unit including an object lens, the object lens guiding the scan of the exciting light into a tissue having a fluorescent matter such that the fluorescent matter in the tissue is excited by the scan of the exciting light and emits fluorescence light, whereby a layer of the tissue is scanned by the scan of the exciting light;

a detection unit that detects and processes the fluorescence light emitted by the tissue, so as to generate a fluorescent image of the one layer of the tissue; and

a splitter unit that directs the exciting light to the scan unit such that the exciting light is converted into the scan of the exciting light by the scan unit, and further directs the fluorescence light emitted by the tissue to the detection unit after the scan of the exciting light enters the tissue via the object lens, such that the fluorescent image of the layer of the tissue is generated by the detection unit.

10. The image detection system of claim 9, wherein the detection unit comprises a filter, a confocal optics, a photomultiplier and a processor, the filter is used to allow the fluorescence light having a particular wavelength emitted by the tissue to enter the photomultiplier, and the confocol optics is used to allow the fluorescence light having the particular wavelength emitted by the one layer of the tissue to reach the photomultiplier, so as for the photomultiplier to receive and convert the fluorescence light having the particular wavelength emitted by the layer of the tissue into an electric signal, and then for the processor to process the electric signal and generate the fluorescent image of the layer of the tissue.

11. The image detection system of claim 9, wherein the splitter unit transmits the exciting light to the scan unit, and further reflects the fluorescence light emitted by the tissue to the detection unit.

12. The image detection system of claim 9, wherein the splitter unit reflects the exciting light to the scan unit, and further transmits the fluorescence light emitted by the tissue to the detection unit.