SYSTEMS AND METHODS FOR EARLY DISEASE DETECTION AND REAL-TIME DISEASE MONITORING
First Claim
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1. A detector device for detecting the presence of one or more biomolecule markers in a biological fluid in a subject comprising:
- a) detection means in fluid communication with a biological fluid capable of obtaining information regarding the identity and concentration of a biomolecule, b) a power supply, and c) means to transmit the information to a receiver-relay unit.
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Abstract
Devices, systems and methods are provided for the real-time detection of disease through constant or periodic monitoring of biomolecules in an individual without laboratory sampling. Biomolecule detector devices may be worn in contact with skin, or be implanted in fluid communication with a biological fluid to provide information and identity of disease-related circulating biomolecules in an individual.
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Citations
72 Claims
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1. A detector device for detecting the presence of one or more biomolecule markers in a biological fluid in a subject comprising:
- a) detection means in fluid communication with a biological fluid capable of obtaining information regarding the identity and concentration of a biomolecule, b) a power supply, and c) means to transmit the information to a receiver-relay unit.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 51, 71)
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21. A system for monitoring biomolecules and determining their identity in a biological fluid of a subject within or leaving the subject comprising:
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a detector unit in fluid communication with a biological fluid, a receiver-relay unit, and a processor unit. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 72)
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- 42. A method of monitoring a subject having no symptoms of disease to determine onset of, or diagnose a disease comprising implanting a detector unit on or in the subject and monitoring changes in the level or presence of one or more biomolecule markers associated with the disease wherein a change in the level or presence of the one or more biomolecule markers indicates presence of the disease.
- 44. A method of monitoring a subject to predict response to treatment for a disease comprising implanting a detector unit on or in the subject and monitoring changes in the level or presence of one or more biomolecule markers associated with a disease wherein a change in the level or presence of the one or more biomolecule markers associated with treatment resistance of the disease indicates the presence or absence of resistance of the subject to a disease treatment.
- 46. A method of monitoring a subject to evaluate efficacy of treatment for a disease by implanting a detector unit on or in the subject and monitoring changes in the level or presence of one or more biomolecule markers associated with a disease wherein a change in the level or presence of the one or more biomolecule markers to resemble a biomolecule profile associated with treatment of the disease indicates efficacy of a disease treatment.
- 48. A method of monitoring prognosis of a disease in a subject, comprising implanting a detector unit in or on a subject and detecting one or more biomolecule markers in a biological fluid from the subject wherein a difference in the levels or presence of a biomolecule marker from the levels or presence in a healthy individual indicates the prognosis of a disease.
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50. A method of monitoring a subject after treatment for a disease to determine efficacy of treatment or early relapse by implanting a detector unit on or in the subject and monitoring changes in the level or presence of one or more target markers associated with a disease wherein a change in the level or presence of the one or more target markers indicates potential relapse of the disease.
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52. A method for monitoring the state of a condition, such as a tumour, in a subject having said condition, said method comprising implanting a detector unit on or in the subject and monitoring changes in the level or presence of one or more biomolecule markers which are known to be associated with the condition, such as determined from a biopsy of the tumour, wherein a change in the level or presence of the one or more biomolecule markers indicates a change in the state of the condition.
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53. A method for monitoring the presence of a condition, such as a tumour, in a subject who has previously had said condition, said method comprising implanting a detector unit on or in the subject and monitoring changes in the level or presence of one or more biomolecule markers which are known to be associated with the condition, such as determined from a biopsy of the tumour, wherein a change in the level or presence of the one or more biomolecule markers indicates the presence of the condition.
Specification