POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS
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Abstract
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
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Citations
21 Claims
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1-20. -20. (canceled)
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21. A device for continuous in vivo measurement of a glucose concentration, the device comprising:
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an implantable sensor configured to continuously measure a signal indicative of a glucose concentration in a host, wherein the implantable sensor comprises an electroactive surface; a membrane located over the sensor, wherein the membrane comprises a first domain comprising an enzyme configured to react with glucose to produce a measured species configured to be oxidized at the sensor, wherein the membrane comprises a second domain comprising a blend comprising; a polymer comprising a hydrophilic segment, wherein the molecular weight of the polymer is from about 25,000 daltons to about 5,000,000 daltons, and a polyurethaneurea, wherein the blend of the polymer and the polyurethaneurea comprises both hydrophilic and hydrophobic regions; and sensor electronics operably connected to the sensor, wherein the sensor electronics are configured to measure a current flow produced by the sensor to generate sensor data indicative of glucose concentration.
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Specification