DYNAMIC BIOACTIVE NANOFIBER SCAFFOLDING
First Claim
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1. A resorbable bone graft scaffold material, comprising:
- a plurality of overlapping and interlinking nonporous, polymer-free bioactive ceramic fibers defining a scaffold structure;
a plurality of pores distributed throughout and defined by the scaffold; and
a plurality of bioactive, resorbable spheres distributed in at least some of the respective pores;
wherein each respective sphere is fused to at least one ceramic fiber;
wherein the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers;
wherein the fibers are a bioactive, resorbable material.
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Abstract
A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.
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Citations
28 Claims
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1. A resorbable bone graft scaffold material, comprising:
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a plurality of overlapping and interlinking nonporous, polymer-free bioactive ceramic fibers defining a scaffold structure; a plurality of pores distributed throughout and defined by the scaffold; and a plurality of bioactive, resorbable spheres distributed in at least some of the respective pores; wherein each respective sphere is fused to at least one ceramic fiber; wherein the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers; wherein the fibers are a bioactive, resorbable material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12-21. -21. (canceled)
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22. A biologically resorbable tissue regrowth scaffold material, comprising:
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a porous support matrix further defining a plurality of overlapping and entangled solid, polymer-free bioactive, resorbable ceramic fibers; a plurality of pores distributed throughout the support matrix; and a plurality of bioactive, resorbable spheres distributed throughout the support matrix; wherein each respective fiber has a diameter from about 5 nanometers to about 100 micrometers. - View Dependent Claims (23, 24, 25, 26, 27)
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28. A tissue regrowth support material, comprising:
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a flexible porous fibrous tissue regrowth support material further comprising a plurality of overlapping and entangled bioactive, biologically resorbable ceramic fibers; a plurality of pores distributed throughout the support material; and a plurality of bioactive, resorbable particles distributed throughout the support matrix.
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Specification