MICROCAPSULES COMPRISING SUNSCREEN AGENTS

• US 20160008237A1
• Filed: 02/27/2014
• Published: 01/14/2016
• Est. Priority Date: 02/28/2013
• Status: Abandoned Application

• Current Assignee: Tagra Biotechnologies Ltd. (EFAL Chemical Industries, Ltd.)
• Original Assignee: Tagra Biotechnologies Ltd. (EFAL Chemical Industries, Ltd.)
• Inventors: GOLDSTEIN, Danny, PRIVALOVA, Olga, BEN-ALTABET, Lior, MENACHEM, Yaniv, HAJ, Hanan
• Application Number:
  US14/770,873
• Publication Number:
  US 20160008237A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 2800/262 Transparent; Translucent
• CPC Class Codes: A61K 2800/30 Characterized by the absence of a particular group of ingredients
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 2800/52 Stabilizers
• CPC Class Codes: A61K 2800/805 Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/29 Titanium; Compounds thereof
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/40 containing nitrogen quinones containing nitrogen A61K8/355
• CPC Class Codes: A61K 8/8152 Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

Microcapsules comprised of a core comprising one or more sunscreen agents and a shell of a wall-forming polymeric material, which are non-rupturable upon rubbing or pressing on the skin, and processes of preparing same are disclosed. Topical formulations comprising the microcapsules, which can be, for example, sunscreen formulations or skin care formulations, are also provided.

Claims

1. A microcapsule comprising a core comprising at least one sunscreen agent and a shell enveloping the core, the shell being comprised of a wall-forming polymeric material comprising at least one polymer or copolymer selected from the group consisting of a polyacrylate, a polymethacrylate, a cellulose ether, a cellulose ester, or any combination thereof, said shell being devoid of a plasticizer, the microcapsule being non-breakable when subjected to homogenization at 2000 rpm for 10 minutes and/or to ultrasonication at 15 W and 28 kHz for 1 minute, and is having a size within a range selected from about 1 μ

m to about 100 μ

m.

5. The microcapsule of claim 1, wherein the shell is transparent.

6. The microcapsule according to claim 1, wherein the sunscreen agent is a water insoluble or water immiscible sunscreen agent.

7. The microcapsule according to claim 6, wherein the sunscreen agent is selected from the group consisting of TiO₂, avobenzone, p-aminobenzoic acid, bemotrizinol, benzophenone-9, bexophenome-3, bisoctrizole, 3-(4-methylbenzylidene)-camphor, cinoxate, diethylamino hydroxybenzoyl hexyl benzoate, dioxybenzone, drometrizole trisiloxane, ecamsule, ethylhexyl triazone, homosalate, menthyl anthranilate, octocrylene, octyl salicylate, iscotrizinol, isopentenyl-4-methoxycinnamate, octyl-dimethyl-p-aminobenzoic acid, octyl-methoxycinnamate, oxybenzone, polysilicone-15, trolamine salicylate, ZnO, and any combination thereof.

8. The microcapsule according to claim 7, wherein the sunscreen agent is TiO₂.

10. The microcapsule according to claim 7, wherein the sunscreen agent is avobenzone.

13. The microcapsule according to claim 7, wherein the sunscreen agent is a blend of TiO₂ and one or more of avobenzone, p-aminobenzoic acid, cinoxate, dioxybenzone, ecamsule, homosalate, menthyl anthranilate, octocrylene, octyl salicylate, octyl-methoxycinnamate, oxybenzone, trolamine salicylate, or ZnO.

16. The microcapsule according to claim 1, wherein the amount of the wall-forming polymeric material is within a range selected from about 20% to about 70%, from about 20% to about 50%, from about 20% to about 40%, or from about 20% to about 30%, or about 20% or 50%, by weight.

18. The microcapsule according to claim 1, further comprising a photostabilizer.

19. The microcapsule according to claim 18, wherein the photostabilizer is selected from the group consisting of diethylhexyl-2,6-naphthalate, octocrylene, ethylhexyl methoxycrylene and 4-methylbenzylidene camphor.

20. The microcapsule according to claim 18, wherein the amount of the photostabilizer in the microcapsule is within a range selected from about 5% to about 50%, from about 5% to about 40%, from about 5% to about 30%, or from about 10% to about 25%, or about 10% by weight.

23. A composition comprising a plurality of microcapsules, at least a portion of the microcapsules comprising a plurality of sunscreen agent-containing microcapsules according to claim 1.

24. The composition of claim 23, wherein the microcapsules in the plurality of sunscreen agent-containing microcapsules are the same or different.

26. The composition according to claim 23, further comprising a photostabilizer.

27. The composition according to claim 23, wherein at least a portion of microcapsules in the plurality of sunscreen agent-containing microcapsules further comprise a photo stabilizer.

28. A process of preparing sunscreen agent-containing microcapsule of claim 1, the process comprising:

(a) mixing a solution comprising the sunscreen agent, a wall-forming polymeric material and an organic solvent, to thereby obtain a homogeneous solution;

(b) mixing the homogeneous solution with an aqueous solution containing an emulsifier, under high shear stirring, to thereby form an emulsion; and

(c) adding to the formed emulsion an amount of water which initiates extraction of the organic solvent from the emulsion, thereby obtaining the microcapsules.

29. The process of claim 28, further comprising isolating the microcapsules.

30. The process of claim 28, further comprising drying and sifting the microcapsules, to thereby obtain a free flowing powder of the microcapsules.

33. A cosmetic or cosmaceutical formulation comprising the composition according to claim 23.

34. The cosmetic or cosmaceutical formulation according to claim 33, further comprising a cosmetically or cosmaceutically acceptable carrier.

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