MICRONIZED INSULIN, MICRONIZED INSULIN ANALOGUES, AND METHODS OF MANUFACTURING THE SAME
First Claim
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1. A method of preparing an inhalable insulin suitable for pulmonary delivery, the method comprising:
- dissolving an insulin raw material in an acidic solution to form a dissolved insulin solution;
titrating the dissolved insulin solution with a buffer solution to form a suspension comprising micronized insulin particles; and
stabilizing the micronized insulin particles.
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Abstract
A method of preparing an inhalable insulin suitable for pulmonary delivery includes: dissolving an insulin raw material in an acidic solution to form a dissolved insulin solution; titrating the dissolved insulin solution with a buffer solution to form a suspension comprising micronized insulin particles; and stabilizing the micronized insulin particles.
8 Citations
28 Claims
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1. A method of preparing an inhalable insulin suitable for pulmonary delivery, the method comprising:
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dissolving an insulin raw material in an acidic solution to form a dissolved insulin solution; titrating the dissolved insulin solution with a buffer solution to form a suspension comprising micronized insulin particles; and stabilizing the micronized insulin particles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. Micronized insulin particles comprising:
substantially spherical particles comprising an insulin selected from the group consisting of human insulin, an animal insulin, an insulin analogue, and a mixture thereof. - View Dependent Claims (26, 27, 28)
Specification