RNA-Guided Targeting of Genetic and Epigenomic Regulatory Proteins to Specific Genomic Loci
First Claim
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1. A fusion protein comprising catalytically inactive CRISPR associated 9 (dCas9) protein linked to a heterologous functional domain.
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Abstract
Methods and constructs for RNA-guided targeting of heterologous functional domains such as transcriptional activators to specific genomic loci.
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Citations
25 Claims
- 1. A fusion protein comprising catalytically inactive CRISPR associated 9 (dCas9) protein linked to a heterologous functional domain.
Specification