Non-Invasive, In-Vivo Measurement of Blood Constituents Using a Portable Nuclear Magnetic Resonance Device

• US 20160011290A1
• Filed: 05/21/2014
• Published: 01/14/2016
• Est. Priority Date: 05/21/2013
• Status: Abandoned Application

• Current Assignee: Iannello, Victor
• Original Assignee: Iannello, Victor
• Inventors: Iannello, Victor
• Application Number:
  US14/771,535
• Publication Number:
  US 20160011290A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0431 Portable apparatus, e.g. comprising a handle or case
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/4875 Hydration status, fluid retention of the body
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: G01R 33/36 Electrical details, e.g. matching or coupling of the coil to the receiver
• CPC Class Codes: G01R 33/448 Relaxometry, i.e. quantification of relaxation times or spin density G01R33/50 takes precedence
• CPC Class Codes: G01R 33/4828 Resolving the MR signals of different chemical species, e.g. water-fat imaging
• CPC Class Codes: G01R 33/5615 Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE]
• CPC Class Codes: G01R 33/56527 due to chemical shift effects
• CPC Class Codes: G01R 33/56563 caused by a distortion of the main magnetic field B0, e.g. temporal variation of the magnitude or spatial inhomogeneity of B0 G01R33/56509, G01R33/56518, G01R33/56536 take precedence

Abstract

Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, applying a static magnetic field induced by one or more permanent magnets to a cup that is configured to receive at least a portion of a digit of an animal.

Claims

1. A method comprising:

via one or more predetermined processors communicatively coupled to sensor coil of a nuclear magnetic resonance instrument;

determining a radio frequency that substantially matches a hydrogen nuclei Larmor frequency for a capillary-rich portion of a digit of a mammal, the capillary-rich portion containing a large amount of blood relative to a bone portion of the digit, the hydrogen nuclei Larmor frequency corresponding to a static magnetic field induced by one or more permanent magnets to cross an air gap between an opposing pair of pole faces that have a transverse spacing sufficient to receive a cup that is configured to receive the digit, a magnitude of the hydrogen nuclei Larmor frequency dependent on a position of the portion of the digit between the pair of pole faces, the radio frequency a measure of time-dependent variation in a longitudinal magnetic field induced by a time-varying current in the sensor coil, the sensor coil substantially surrounding the cup and defining a coil axis oriented substantially parallel to a longitudinal axis of the cup;

while the longitudinal magnetic field is applied to the digit, acquiring an amplitude and a spin-spin relaxation time of each of a train of spin echoes created by applying a plurality of CPMG pulses to the digit via the sensor coil, a count of the spin echoes in the train of spin echoes corresponding to a decay of the spin echo amplitudes to a predetermined value;

based on the amplitudes of the spin echoes, determining a distribution of spin-spin relaxation time constants of a plurality of components in the blood; and

for each of the one or more predetermined components, based on the distribution of spin-spin relaxation time constants, determining a relative concentration of the predetermined component in the blood.

2. The method of claim 1, further comprising:

repeating said acquiring for a predetermined number of repetitions.

3. The method of claim 1, further comprising:

repeating said acquiring for a predetermined number of repetitions, each repetition delayed by a wait time that is greater than a spin lattice relaxation time of one or more predetermined components of the plurality of components.

4. The method of claim 1, further comprising:

repeating said acquiring for a predetermined number of repetitions, each repetition delayed by a wait time that is less than a spin lattice relaxation time of one or more predetermined components of the plurality of components.

5. The method of claim 1, further comprising:

repeating said acquiring for a predetermined number (N) of repetitions such that a plurality of echo trains is acquired, each echo train comprising a plurality echoes, each echo from each echo train having a corresponding sequential position in that echo train; and

for the plurality of echo trains, for each sequential position, summing an amplitude of the corresponding echoes, such that all first echoes are summed together, all second echoes are summed together, and all N echoes are summed together.

6. The method of claim 1, further comprising:

repeating said acquiring for a predetermined number of repetitions; and

summing similarly timed echoes across the predetermined number of repetitions.

7. The method of claim 1, further comprising:

rendering the relative concentration of the one or more predetermined component in the blood.

8. The method of claim 1, wherein:

at least one of the one or more processors is communicatively coupled to the sensor coil via a network.

9. A method comprising:

via one or more predetermined processors communicatively coupled to sensor coil of a nuclear magnetic resonance instrument;

for each of one or more predetermined components of a plurality of components in blood of a digit of a mammal, based on a distribution of spin-spin relaxation time constants for hydrogen nuclei of the predetermined component, determining a relative concentration of the predetermined component in the blood, the distribution of spin-spin relaxation time constants determined based on amplitudes of a train of spin echoes created by a plurality of CPMG pulses applied to the digit by a sensor coil while a longitudinal magnetic field is applied to the digit, a count of the spin echoes in the train of spin echoes corresponding to decay of the spin echoes to a predetermined value, the sensor coil substantially surrounding a cup and defining a coil axis oriented substantially parallel to a longitudinal axis of the cup, the cup configured to receive the digit, the cup located within a transverse spacing between an opposing pair of pole faces of one or more permanent magnets, the transverse spacing defining an air gap across which the one or more permanent magnets are configured to produce a static magnetic field, the static magnetic field configured to induce hydrogen nuclei of the digit to precess at a corresponding Larmor frequency, the Larmor frequency of each hydrogen nuclei having a magnitude that is dependent on a position of a portion of the digit between the pair of pole faces, a time-dependent variation in the longitudinal magnetic field applied by a time-varying current in the sensor coil having a frequency substantially matching the Larmor frequency for a capillary-rich portion of the digit, the capillary-rich portion containing a large amount of blood relative to a bone portion of the digit.

10. A method comprising:

via one or more predetermined processors communicatively coupled to sensor coil of a nuclear magnetic resonance instrument;

determining a radio frequency that substantially matches a hydrogen nuclei Larmor frequency for a capillary-rich portion of a digit of a mammal, the capillary-rich portion containing a large amount of blood relative to a bone portion of the digit, the hydrogen nuclei Larmor frequency corresponding to a static magnetic field induced one or more permanent magnets to cross an air gap between an opposing pair of pole faces that have a transverse spacing sufficient to receive a cup that is configured to receive the digit, a magnitude of the hydrogen nuclei Larmor frequency dependent on a position of the portion of the digit between the pair of pole faces, the radio frequency a measure of time-dependent variation in a longitudinal magnetic field induced by a time-varying current in the sensor coil, the sensor coil substantially surrounding the cup and defining a coil axis oriented substantially parallel to a longitudinal axis of the cup.

11. A device, comprising:

a cup configured to receive at least a terminal portion of a digit of a mammal, the cup defining a cup longitudinal axis;

one or more permanent magnets configured to induce a static magnetic field to cross an air gap located between an opposing pair of pole faces that have a transverse spacing sufficient to receive the cup;

a sensor coil substantially surrounding the cup, defining a coil axis oriented substantially parallel to a longitudinal axis of the cup, and configured to produce a longitudinal magnetic field that varies with respect to time responsive to application of a time-varying current to the sensor coil;

wherein;

the static magnetic field is configured to induce hydrogen nuclei of the digit to precess at a corresponding Larmor frequency;

the Larmor frequency of each hydrogen nuclei has a magnitude that is dependent on a position of a portion of the digit between the pair of pole faces;

the time-dependent variation in the longitudinal magnetic field has a frequency substantially matching a Larmor frequency for a capillary-rich portion of the digit, the capillary-rich portion containing a large amount of blood relative to a bone portion of the digit.

12. A device, comprising:

a cup configured to receive at least a terminal portion of a digit of a mammal, the cup defining a cup longitudinal axis;

one or more permanent magnets configured to induce a static magnetic field to cross an air Thanks Kelly.

gap located between an opposing pair of pole faces that have a transverse spacing sufficient to receive the cup;

a sensor coil substantially surrounding the cup, defining a coil axis oriented substantially parallel to a longitudinal axis of the cup, and configured to produce a longitudinal magnetic field that varies with respect to time responsive to application of a time-varying current to the sensor coil;

wherein;

the sensor coil is configured to acquire a train of spin echoes created by a plurality of CPMG pulses applied to the digit by a sensor coil while the longitudinal magnetic field is applied to the digit, the train of spin echoes defining amplitudes and corresponding spin-spin relaxation times, the amplitudes and spin-spin relaxation times corresponding to a distribution of spin-spin relaxation time constants for hydrogen nuclei of a predetermined component of a plurality of components of blood of the mammal, the distribution corresponding to a relative concentration of the predetermined component in the blood.