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Non-Invasive, In-Vivo Measurement of Blood Constituents Using a Portable Nuclear Magnetic Resonance Device

  • US 20160011290A1
  • Filed: 05/21/2014
  • Published: 01/14/2016
  • Est. Priority Date: 05/21/2013
  • Status: Abandoned Application
First Claim
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1. A method comprising:

  • via one or more predetermined processors communicatively coupled to sensor coil of a nuclear magnetic resonance instrument;

    determining a radio frequency that substantially matches a hydrogen nuclei Larmor frequency for a capillary-rich portion of a digit of a mammal, the capillary-rich portion containing a large amount of blood relative to a bone portion of the digit, the hydrogen nuclei Larmor frequency corresponding to a static magnetic field induced by one or more permanent magnets to cross an air gap between an opposing pair of pole faces that have a transverse spacing sufficient to receive a cup that is configured to receive the digit, a magnitude of the hydrogen nuclei Larmor frequency dependent on a position of the portion of the digit between the pair of pole faces, the radio frequency a measure of time-dependent variation in a longitudinal magnetic field induced by a time-varying current in the sensor coil, the sensor coil substantially surrounding the cup and defining a coil axis oriented substantially parallel to a longitudinal axis of the cup;

    while the longitudinal magnetic field is applied to the digit, acquiring an amplitude and a spin-spin relaxation time of each of a train of spin echoes created by applying a plurality of CPMG pulses to the digit via the sensor coil, a count of the spin echoes in the train of spin echoes corresponding to a decay of the spin echo amplitudes to a predetermined value;

    based on the amplitudes of the spin echoes, determining a distribution of spin-spin relaxation time constants of a plurality of components in the blood; and

    for each of the one or more predetermined components, based on the distribution of spin-spin relaxation time constants, determining a relative concentration of the predetermined component in the blood.

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