Method of Producing Testosterone Formulation and Testosterone Formulation Produced Thereby
First Claim
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1. A method of producing a testosterone formulation, comprising the steps of:
- A. dissolving testosterone propionate, dibucaine HCl, and methylal in alcohol to form a first solution;
B. heating polyethylene glycol 400 and polyethylene glycol 4000 to about 60 to 90°
C. such that the polyethylene glycol 400 and the polyethylene glycol 4000 are dissolved and form a second solution, and stirring the second solution evenly; and
C. cooling the second solution obtained from step B to 25 to 75°
C. at a cooling rate lower than 0.06°
C./sec, adding the cooled second solution into the first solution obtained from step A to form a third solution, stirring the third solution incessantly to facilitate emulsification, and, while the third solution keeps cooling down, stirring the third solution incessantly until the third solution is emulsified into an ointment.
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Abstract
The present invention is about a method of producing testosterone formulation and the testosterone formulation produced thereby. The method of this invention comprises dissolving testosterone propionate and dibucaine HCl in alcohol, adding particular percentages of polyethylene glycol 400 and polyethylene glycol 4000, and cooling under particular speed to produce the testosterone formulation which has the advantages of moderate viscosity, easy to use and excellent particle consistency.
4 Citations
10 Claims
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1. A method of producing a testosterone formulation, comprising the steps of:
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A. dissolving testosterone propionate, dibucaine HCl, and methylal in alcohol to form a first solution; B. heating polyethylene glycol 400 and polyethylene glycol 4000 to about 60 to 90°
C. such that the polyethylene glycol 400 and the polyethylene glycol 4000 are dissolved and form a second solution, and stirring the second solution evenly; andC. cooling the second solution obtained from step B to 25 to 75°
C. at a cooling rate lower than 0.06°
C./sec, adding the cooled second solution into the first solution obtained from step A to form a third solution, stirring the third solution incessantly to facilitate emulsification, and, while the third solution keeps cooling down, stirring the third solution incessantly until the third solution is emulsified into an ointment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Current AssigneeHygica Biotech Inc.
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Original AssigneeHygica Biotech Inc.
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InventorsLEE, Chien-Hung, LIN, Cheng-Chieh
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Application NumberUS14/507,547Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current1/1CPC Class CodesA61K 31/568 substituted in positions 10...
