SYSTEM AND METHOD OF VARIABLE DOSE GLUCAGON DELIVERY
First Claim
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1. A system for variable dose glucagon delivery to a patient without the need to manually reconstitute the glucagon comprising:
- a reconstitution mechanism comprising;
a reconstitution chamber disposed between an inlet and an outlet;
a stabilized solute form of glucagon;
a solute delivery mechanism for metered dosing of said solute glucagon into said reconstitution chamber;
a diluent supply in fluid communication with said reconstitution chamber;
an activation switch that triggers said solute delivery mechanism to provide a metered dose of said solute glucagon into said reconstitution chamber, and triggers said diluent supply to provide a metered dose of a diluent into said reconstitution chamber; and
,a delivery mechanism disposed in fluid communication with said outlet to controllably provide a predetermined amount of a soluble glucagon solution to a tissue of said patient.
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Abstract
Disclosed are systems and methods for variable dose glucagon delivery without the need to manually reconstitute the glucagon. These systems and methods mat be utilized with or without a separate continuous glucose monitor. The variability of the dose may be determined manually by the user, caregiver or responder, or by preprogrammed algorithms utilizing the input from an external sensor such as a continuous glucose monitor.
4 Citations
24 Claims
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1. A system for variable dose glucagon delivery to a patient without the need to manually reconstitute the glucagon comprising:
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a reconstitution mechanism comprising; a reconstitution chamber disposed between an inlet and an outlet; a stabilized solute form of glucagon; a solute delivery mechanism for metered dosing of said solute glucagon into said reconstitution chamber; a diluent supply in fluid communication with said reconstitution chamber; an activation switch that triggers said solute delivery mechanism to provide a metered dose of said solute glucagon into said reconstitution chamber, and triggers said diluent supply to provide a metered dose of a diluent into said reconstitution chamber; and
,a delivery mechanism disposed in fluid communication with said outlet to controllably provide a predetermined amount of a soluble glucagon solution to a tissue of said patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for providing a variable dose of glucagon that is delivered to a patient without the need to manually reconstitute the glucagon comprising:
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metering and dispensing a dose of stabilized solute form of glucagon to a reconstitution chamber; metering and dispensing a diluent dose to said reconstitution chamber to create a soluble glucagon solution of predetermined concentration; triggering a release of said glucagon solution from said reconstitution chamber based upon a physiological condition of said patient; and
,controllably delivering said released glucagon solution to provide a predetermined amount of said soluble glucagon solution to a tissue of said patient. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification