MULTI-CHAMBER INTRACARDIAC PACING SYSTEM

• US 20160015984A1
• Filed: 03/11/2015
• Published: 01/21/2016
• Est. Priority Date: 07/17/2014
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Demmer, Wade M., Sheldon, Todd J., Greenhut, Saul E., Reinke, James D.
• Granted Patent: US 10,441,796 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability
• CPC Class Codes: A61N 1/3706 Pacemaker parameters stimulation threshold A61N1/371
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

The control module of a first pacemaker included in an implantable medical device system including the first pacemaker and a second pacemaker is configured to set a pacing escape interval in response to a far field pacing pulse sensed by the first pacemaker. The far field pacing pulse is a pacing pulse delivered by the second pacemaker. The pacing escape interval is allowed to continue without restarting the in response to a far field intrinsic event sensed by the first pacemaker during the pacing escape interval. The first pacemaker delivers a cardiac pacing pulse to the heart upon expiration of the pacing escape interval.

Claims

1. A medical device system, comprising

a first implantable pacemaker;

and

a second implantable pacemaker;

the first implantable pacemaker comprising;

a first sensing module configured to receive a first cardiac electrical signal via a pair of electrodes and sense from the cardiac electrical signal near field intrinsic cardiac events occurring in a first heart chamber, far field intrinsic events occurring in a second heart chamber different than the first heart chamber, and far field pacing pulses, the far field pacing pulses being pacing pulses delivered in the second heart chamber by the second implantable pacemaker;

a first pulse generator coupled to the pair electrodes for delivering a cardiac pacing pulse to the first heart chamber; and

a first control module configured to;

set a first pacing escape interval in response to a far field pacing pulse sensed by the first sensing module;

permit the first pacing escape interval to continue without restarting the first pacing escape interval in response to a far field intrinsic event sensed by the first sensing module during the first pacing escape interval; and

control the pulse generator to deliver the cardiac pacing pulse to the first heart chamber upon expiration of the first pacing escape interval.

2. The system of claim 1, wherein the first control module is further configured to set a second pacing escape interval different than the first pacing escape interval in response to a far field intrinsic event sensed by the first sensing module outside the first pacing escape interval.

3. The system of claim 2, wherein the first control module is configured to:

detect a tachycardia of the second heart chamber in response to the far-field intrinsic events sensed by the first sensing module; and

disable setting the first and second escape intervals in response to detecting the tachycardia.

4. The system of claim 3, wherein the first control module is configured to detect the tachycardia by detecting a decrease in a rate of the far-field intrinsic events sensed by the first sensing module below a predetermined minimum rate.

5. The system of claim 3, wherein the first control module is configured to detect the tachycardia by detecting an increase of the far-field intrinsic events sensed by the first sensing module, the increase being above a predetermined pacing mode switch threshold.

6. The system of claim 2, wherein the first control module is further configured to:

start an extended first pacing escape interval in response to a next far field pacing pulse event sensed by the first sensing module;

determine a conduction time from the next far field pacing pulse event to a next near field intrinsic event sensed during the extended first pacing escape interval;

compare the conduction time to a conduction time range; and

responsive to the conduction time being within the conduction time range, set a back-up pacing interval in response to each one of a plurality of subsequent far field pacing pulse events, the back-up pacing interval being greater than the first pacing escape interval.

7. The system of claim 6, wherein the control module is further configured to:

control the pulse generator to deliver a back-up pacing pulse to the first heart chamber upon expiration of the back-up pacing interval; and

set the first pacing escape interval in response to a far field pacing pulse event sensed by the first sensing module after the back-up pacing pulse.

8. The system of claim 1, wherein the second implantable pacemaker comprises:

a second sensing module configured to receive a second cardiac electrical signal via a second pair of electrodes and sense from the second cardiac electrical signal second far field pacing pulse events that are first pacing pulses delivered in the first heart chamber by the first implantable pacemaker;

a second pulse generator coupled to the second pair of electrodes for delivering second cardiac pacing pulses to the second heart chamber; and

a second control module configured to;

set a first pacing pulse output for controlling the second cardiac pacing pulses that are delivered to the second heart chamber in response to not sensing the second far field pacing pulse events by the second sensing module; and

set a second pacing pulse output for controlling the second cardiac pacing pulses that are delivered to the second heart chamber in response to sensing the second far field pacing pulse events by the second sensing module, the second pacing pulse output greater than the first pacing pulse output.

9. The system of claim 8, wherein the second control module is configured to:

set the first pacing pulse output by setting a first pacing safety margin;

set the second pacing pulse output by setting a second pacing safety margin greater than the first pacing safety margin.

10. The system of claim 1, wherein:

the first control module is configured to set a blanking interval in response to the far field pacing pulse, the blanking interval set to expire prior to an expected far field evoked response event;

the first sensing module is configured to sense a far field evoked response following the blanking interval; and

the first control module is configured to set the first pacing escape interval in response to the far field pacing pulse by starting the first pacing escape interval upon the far field evoked response sensed after the blanking interval.

11. A method performed by an implantable medical device system including a first implantable pacemaker and a second implantable pacemaker, the method comprising:

sensing from a cardiac electrical signal received by a first sensing module of the first implantable pacemaker;

near field intrinsic cardiac events occurring in a first heart chamber,

far field intrinsic events occurring in a second heart chamber different than the first heart chamber, and

far field pacing pulses, the far field pacing pulses being pacing pulses delivered in the second heart chamber by the second implantable pacemaker;

setting a first pacing escape interval in response to a far field pacing pulse sensed by the first sensing module;

allowing the first pacing escape interval to continue without restarting the first pacing escape interval in response to a far field intrinsic event sensed by the first sensing module during the first pacing escape interval; and

controlling a pulse generator to deliver a cardiac pacing pulse to the first heart chamber upon expiration of the first pacing escape interval.

12. The method of claim 11, further comprising setting a second pacing escape interval different than the first pacing escape interval in response to a far field intrinsic event sensed by the first sensing module outside the first pacing escape interval.

13. The method of claim 12, further comprising:

detecting a tachycardia of the second heart chamber in response to the far-field intrinsic events sensed by the first sensing module; and

disabling setting the first and second escape intervals in response to detecting the tachycardia.

14. The method of claim 13, wherein detecting the tachycardia comprises detecting a decrease in a rate of the far-field intrinsic events sensed by the first sensing module below a predetermined minimum rate.

15. The method of claim 13, wherein detecting the tachycardia comprises detecting an increase of the far-field intrinsic events sensed by the first sensing module above a predetermined pacing mode switch threshold.

16. The method of claim 12, further comprising:

starting an extended first pacing escape interval in response to a next far field pacing pulse event sensed by the first sensing module;

determining a conduction time from the next far field pacing pulse event to a next near field intrinsic event sensed during the extended first pacing escape interval;

comparing the conduction time to a conduction time range; and

responsive to the conduction time being within the conduction time range, setting a back-up pacing interval in response to each one of a plurality of subsequent far field pacing pulse events, the back-up pacing interval being greater than the first pacing escape interval.

17. The method of claim 16, further comprising:

controlling the pulse generator to deliver a back-up pacing pulse to the first heart chamber upon expiration of the back-up pacing interval; and

setting the first pacing escape interval in response to a far field pacing pulse event sensed by the first sensing module after the back-up pacing pulse.

18. The method of claim 11, further comprising:

sense from a second cardiac electrical signal received by a second sensing module of the second implantable pacemaker second far field pacing pulse events that are pacing pulses delivered in the first heart chamber by the first implantable pacemaker;

setting a first pacing pulse output for controlling second cardiac pacing pulses that are delivered to the second heart chamber, the first pacing pulse output set in response to not sensing the second far field pacing pulse events by the second sensing module; and

setting a second pacing pulse output for controlling the second cardiac pacing pulses that are delivered to the second heart chamber, the second pacing pulse output set in response to sensing the second far field pacing pulse events by the second sensing module, the second pacing pulse output greater than the first pacing pulse output.

19. The method of claim 18, further comprising:

setting the first pacing pulse output by setting a first pacing safety margin;

setting the second pacing pulse output by setting a second pacing safety margin greater than the first pacing safety margin.

20. The method of claim 11, wherein setting the first pacing escape interval in response to the far field pacing pulse comprises:

setting a blanking interval in response to the far field pacing pulse, the blanking interval set to expire prior to an expected far field evoked response event;

sensing a far field evoked response following the blanking interval; and

starting the first pacing escape interval upon sensing the far field evoked response after the blanking interval.

21. A non-transitory, computer-readable storage medium storing a set of instructions that, when executed by a control module of a first implantable pacemaker of an medical device system including the first implantable pacemaker and a second implantable pacemaker, cause the system to:

sense from a cardiac electrical signal received by a first sensing module of the first implantable pacemaker near field intrinsic cardiac events occurring in a first heart chamber, far field intrinsic events occurring in a second heart chamber different than the first heart chamber, and far field pacing pulses, the far field pacing pulses being pacing pulses delivered in the second heart chamber by the second implantable pacemaker;

setting a first pacing escape interval in response to a far field pacing pulse sensed by the first sensing module;

allowing the first pacing escape interval to continue without restarting the first pacing escape interval in response to a far field intrinsic event sensed by the sensing module during the first pacing escape interval; and

controlling a pulse generator to deliver a cardiac pacing pulse to the first heart chamber upon expiration of the first pacing escape interval.