IMPROVED FLUID SAMPLING SYSTEM

• US 20160022191A1
• Filed: 04/16/2014
• Published: 01/28/2016
• Est. Priority Date: 04/17/2013
• Status: Active Grant

• Current Assignee: Fluisense APS
• Original Assignee: Fluisense APS
• Inventors: Velschow, Sten, Madsen, Martin Toft
• Granted Patent: US 10,743,804 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150259 Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150946 Means for varying, regulating, indicating or limiting the speed or time of blood collection
• CPC Class Codes: A61B 5/150992 Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves tubing connectors and couplings A61M39/00
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: G01N 1/14 Suction devices, e.g. pumps; Ejector devices
• CPC Class Codes: G01N 1/28 Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Qmounting specimens on microscopic slides G02B21/34; means for supporting the objects or the materials to be analysed in electron microscopes H01J37/20 ; laboratory gas handling apparatus B01L5/00

Abstract

A fluid sampling system comprising a housing, a first pump means for withdrawing at least one fluid sample from a first sample site, means for returning at least part of the at one fluid sample to a second sample site, transferring means for transferring at least one volume of the at least one first fluid to a sampling means, second pump means for providing at least one active substance, at least one connection to a reservoir containing the at least one active substance, and at least one energy source for driving at least the first and second pump means.

Claims

1. A fluid sampling system comprising;

a housing,

first pump means for withdrawing at least one fluid sample from a first sample site,

means for returning at least part of the at least one fluid sample to a second sample site,

transferring means for transferring at least one volume of the at least one first fluid to a sampling means,

second pump means for providing at least one active substance at the first sample site,

at least one connection to a reservoir containing the at least one active substance, and

at least one energy source for driving at least the first and second pump means, and

wherein fluid sampling system is adapted for withdrawing at least one fluid sample simultaneously as returning at least part of the at least one fluid sample.

2. A fluid sampling system according to claim 1, wherein the at least one active substance is added at and/or near the first sample site

3. A fluid sampling system according to claim 1, wherein the at least one active substance comprises an anti-coagulant.

4. A fluid sampling system according to claim 1, wherein the reservoir of the at least one active substance is arranged inside the housing.

5. A fluid sampling system according to claim 1, further comprising means for filling the reservoir.

6. A fluid sampling system according to claim 1, further comprising one or more catheters for withdrawing the fluid sample, returning at least part of the fluid sample and/or providing the at least one active substance.

7. A fluid sampling system according to claim 3, wherein the anticoagulant is sodiumcitrate.

8. A fluid sampling system according to claim 1, wherein the active substance is used as an internal reference for calibrating a sensor.

9. A fluid sampling system according claim 1, wherein the active substance is used as a reference for accurately determining a concentration of another substance.

10. Method for sampling a body fluid comprising the steps of

providing an active substance through a second lumen at or near a first sample site during time interval Δ

t,

continuously or periodically during time interval At withdrawing a fluid sample through a first lumen from the first sample site, and

automatically transferring at least part of the fluid sample to a sampling means for storage and/or analysis

returning at least part of the fluid not transferred to the sampling means through a third lumen.

11. (canceled)