NANOPARTICLES FOR MITOCHONDRIAL TRAFFICKING OF AGENTS
First Claim
Patent Images
1. A nanoparticle, comprising:
- a hydrophobic nanoparticle core;
a hydrophilic layer surrounding the core; and
a mitochondrial targeting moiety,wherein the nanoparticle has a diameter of about 200 nanometers or less and has a zeta potential of about 0 mV or greater.
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Abstract
Nanoparticles include a core, a hydrophilic layer around the core, and one or more mitochondrial targeting moieties, and may optionally include one or more contrast agents or one or more therapeutic agents. For effective mitochondrial targeting the nanoparticles have a diameter of about 200 nm or less or have a zeta potential of about 0 mV or more.
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Citations
29 Claims
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1. A nanoparticle, comprising:
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a hydrophobic nanoparticle core; a hydrophilic layer surrounding the core; and a mitochondrial targeting moiety, wherein the nanoparticle has a diameter of about 200 nanometers or less and has a zeta potential of about 0 mV or greater. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 28)
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25-27. -27. (canceled)
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29-44. -44. (canceled)
Specification