METHOD FOR EXTRACORPOREAL REMOVAL OF PATHOGENIC MICROBE, AN INFLAMMATORY CELL OR AN INFLAMMATORY PROTEIN FROM BLOOD
First Claim
1. A method for treating a subject in need thereof, by extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein, said method comprising:
- a) contacting said subject'"'"'s whole blood with heparin immobilized on a solid substrate, wherein said heparin is covalently linked by end-point attachment under conditions allowing binding of said pathogenic microbe, said inflammatory cell or said inflammatory protein to the heparin;
b) separating the whole blood from the solid substrate; and
c) recovering said whole blood containing a reduced amount of said pathogenic microbe, said inflammatory cell or said inflammatory protein.
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Accused Products
Abstract
The present invention relates to a method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from mammalian blood/use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, for extracorporeal removal of said pathogenic microbe, inflammatory cell or inflammatory protein from mammalian blood/use of a carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by said pathogenic microbe, inflammatory cell or inflammatory protein and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by a pathogenic microbe, an inflammatory cell or an inflammatory protein.
19 Citations
17 Claims
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1. A method for treating a subject in need thereof, by extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein, said method comprising:
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a) contacting said subject'"'"'s whole blood with heparin immobilized on a solid substrate, wherein said heparin is covalently linked by end-point attachment under conditions allowing binding of said pathogenic microbe, said inflammatory cell or said inflammatory protein to the heparin; b) separating the whole blood from the solid substrate; and c) recovering said whole blood containing a reduced amount of said pathogenic microbe, said inflammatory cell or said inflammatory protein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification