RANDOM ARRAY DNA ANALYSIS BY HYBRIDIZATION
First Claim
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1. An apparatus for determining sequence information for a target nucleic acid by probe hybridization, comprising:
- a sample integration module configured for mixing, introducing, and/or removing reagents;
a disposable plug-in reaction cartridge configured for contacting an array of target nucleic acid fragments with probe pools, wherein the reaction cartridge comprises a slot for securing an array of single DNA molecules or amplicons, and quick connect ports for flow-through connection to the sample integration module;
a subsystem configured for illuminating fluorophores on an array in the reaction cartridge; and
a subsystem configured for detecting fluorophores on an array in the reaction cartridge.
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Abstract
The invention relates to methods and devices for analyzing single molecules, i.e., nucleic acids. Such single molecules may be derived from natural samples, such as cells, tissues, soil, air and water without separating or enriching individual components. In certain aspects of the invention, the methods and devices are useful in performing nucleic acid sequence analysis by probe hybridization.
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Citations
10 Claims
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1. An apparatus for determining sequence information for a target nucleic acid by probe hybridization, comprising:
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a sample integration module configured for mixing, introducing, and/or removing reagents; a disposable plug-in reaction cartridge configured for contacting an array of target nucleic acid fragments with probe pools, wherein the reaction cartridge comprises a slot for securing an array of single DNA molecules or amplicons, and quick connect ports for flow-through connection to the sample integration module; a subsystem configured for illuminating fluorophores on an array in the reaction cartridge; and a subsystem configured for detecting fluorophores on an array in the reaction cartridge. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification