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METHODS AND COMPOSITIONS FOR MODULATING NUCLEASE-MEDIATED GENOME ENGINEERING IN HEMATOPOIETIC STEM CELLS

  • US 20160024474A1
  • Filed: 07/23/2015
  • Published: 01/28/2016
  • Est. Priority Date: 07/25/2014
  • Status: Active Grant
First Claim
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1. A method for increasing nuclease-mediated gene modification in a population of stem cells, wherein the stem cells comprise exogenous nucleases that cleave the genomes of the stem cells, the method comprisingculturing the stem cells in the presence of a histone deactylase inhibitor (HDACI).

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