METHODS FOR MONITORING C9ORF72 EXPRESSION
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Abstract
Disclosed herein are methods for monitoring expression of C9ORF72 mRNA and protein in an animal with C9ORF72 specific inhibitors. Such C9ORF72 specific inhibitors include antisense compounds.
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Citations
133 Claims
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1-99. -99. (canceled)
- 100. A method comprising normalizing expression of any of EDN1, NEDD4L, FAM3C, CHRDL1, CP, SEPP1, SERPINE2, C3, EDNRB2, or Endothelin in a cell by administering to the cell an amount of a compound comprising an oligonucleotide consisting of 12 to 30 linked nucleosides, wherein the oligonucleotide is at least 90% complementary to a C9ORF72 nucleic acid.
- 101. A method comprising reducing nuclear retention of any of ADARB2, CYP2C9, DPH2, HMGB2, JARID2, MITF, MPP7, NDST1, NUDT6, ORAOV1, PGA5, PTER, RANGAP1, SOX6, TCL1B, TRIM32, WBP11, or ZNF695 in a cell by administering to the cell an amount of a compound comprising an oligonucleotide consisting of 12 to 30 linked nucleosides, wherein the oligonucleotide is at least 90% complementary to a C9ORF72 nucleic acid.
Specification