DNA SEQUENCING WITH NON-FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS AND CLEAVABLE LABEL MODIFIED NUCLEOTIDE TERMINATORS
First Claim
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1. A method for determining the identity of each of a series of consecutive nucleotide residues in a nucleic acid comprising:
- a) contacting a plurality of the nucleic acids with (i) a dideoxynucleotide triphosphate (ddNTP) analogue having the structure;
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Abstract
This invention provides a process for sequencing nucleic acids using 3′ modified deoxynucleotide analogues or 3′ modified deoxyinosine triphosphate analogues, and 3′ modified dideoxynucleotide analogues having a detectable marker attached to a base thereof.
23 Citations
81 Claims
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1. A method for determining the identity of each of a series of consecutive nucleotide residues in a nucleic acid comprising:
a) contacting a plurality of the nucleic acids with (i) a dideoxynucleotide triphosphate (ddNTP) analogue having the structure; - View Dependent Claims (60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70)
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2-59. -59. (canceled)
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71. A deoxyribonucleic acid having attached at a 3′
- end thereof, by a phosphodiester bond, a compound having the structure;
- View Dependent Claims (72, 73)
- end thereof, by a phosphodiester bond, a compound having the structure;
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74. A method for determining the identity of each of a series of consecutive nucleotide residues in a nucleic acid comprising:
a) contacting a plurality of the nucleic acids with (i) at least four different dideoxynucleotide triphosphate (ddNTP) analogues, each having the structure; - View Dependent Claims (75, 76, 77, 78, 79, 80, 81)
Specification