POSITIVE PRESSURE INSPIRATION DEVICE FOR DELIVERY OF MEDICAMENTS

• US 20160030701A1
• Filed: 07/29/2015
• Published: 02/04/2016
• Est. Priority Date: 07/29/2014
• Status: Abandoned Application

• Current Assignee: Peter Edenhoffer
• Original Assignee: Peter Edenhoffer
• Inventors: Edenhoffer, Peter
• Application Number:
  US14/812,887
• Publication Number:
  US 20160030701A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 11/00 Sprayers or atomisers specially adapted for therapeutic purposes in general B05B; aerosol containers B65D83/14
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 11/06 of the injector type
• CPC Class Codes: A61M 16/0006 with means for creating vibrations in patients' airways
• CPC Class Codes: A61M 16/0063 Compressors
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/0683 Holding devices therefor
• CPC Class Codes: A61M 16/0875 Connecting tubes
• CPC Class Codes: A61M 16/1065 in the expiratory path
• CPC Class Codes: A61M 16/14 by mixing different fluids, one of them being in a liquid phase
• CPC Class Codes: A61M 16/201 Controlled valves
• CPC Class Codes: A61M 16/208 Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
• CPC Class Codes: A61M 2016/0024 with an on-off output signal, e.g. from a switch
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2202/0427 Platelets; Thrombocytes
• CPC Class Codes: A61M 2202/0437 Blood stem cells
• CPC Class Codes: A61M 2202/07 Proteins
• CPC Class Codes: A61M 2205/3331 Pressure; Flow

Abstract

A respiratory system includes a pressurized gas source coupled to a nebulizer containing a medicament. The nebulizer is connected to a breathing unit. A pressure sensitive switch detects negative pressure at the breathing unit due to inspiration and opens to provide pressured gas flow to the nebulizer. The pressure sensitive switch is configured to close prior to the end of inspiration. Residual medicament disposed in the system is cleared from the system and delivered to the patient during the remainder of the inspiration cycle. A compressor provides positive pressure to aid delivery of medicaments to the patient.

Claims

1. A respiratory system for delivery of a medicament to a patient, comprising;

a pressurized gas source;

a nebulizer containing a medicament, the nebulizer being configured to receive pressurized gas from the pressurized gas source to nebulize at least a portion of the medicament, and to direct nebulized medicament toward a breathing unit configured to deliver nebulized medicament to the patient; and

a pressure sensitive switch associated with the pressurized gas source and the breathing unit, wherein the pressure sensitive switch is configured to open upon a first threshold negative pressure level to release pressurized gas, and to close upon a second threshold negative pressure level, the first and second threshold levels occurring during an inspiratory phase of a respiratory cycle.

2. The respiratory system of claim 1, wherein the first threshold negative pressure level is set at a level that occurs at an initial portion of an inspiratory phase of a respiratory cycle.

3. The respiratory system of claim 1, wherein the second threshold negative pressure is set at a level that occurs prior to the end of an inspiratory phase of a respiratory cycle.

4. The respiratory system of claim 1, wherein the pressure sensitive switch is connected to the breathing unit by a trigger hose, the trigger hose enabling negative pressure during inspiration to be detected by the pressure sensitive switch.

5. The respiratory system of claim 1, wherein the medicament includes cells.

6. The respiratory system of claim 1, wherein the medicament includes one or more of stem cells, platelets, growth factors, cytokines, and hyaluronidase.

7. The respiratory system of claim 1, wherein the medicament includes a suspension of 5 to 45 micrograms of cells in a solution having a hyaluronidase concentration of 1 to 20 mg/ml.

8. The respiratory system of claim 7, wherein the medicament is at a substantially neutral pH.

9. The respiratory system of claim 1, further comprising a compressor in fluid communication with the breathing unit, the compressor configured to provide positive air pressure to the breathing unit.

10. The respiratory system of claim 9, wherein the compressor is coupled to the breathing unit at a location between the nebulizer and the breathing unit.

11. The respiratory system of claim 9, wherein the compressor is disposed proximal to the nebulizer and the pressurized gas source is disposed distal to the nebulizer.

12. The respiratory system of claim 1, further comprising a one-way valve disposed between the nebulizer and the breathing unit and configured to prevent backflow of gas toward the nebulizer.

13. The respiratory system of claim 1, further comprising an exhaust manifold coupled to the breathing unit, the exhaust manifold including a one-way valve configured to prevent flow of nebulized medicament into the exhaust manifold during inspiration.

14. The respiratory system of claim 1, wherein the second threshold pressure level is a greater negative pressure than the first threshold pressure level.

15. The respiratory system of claim 1, wherein the breathing unit includes a nasal adaptor configured to deliver a medicament toward the cribriform plate of the patient.

16. The respiratory system of claim 15, further comprising a compressor configured to provide positive pressure to the nasal adaptor at a variable frequency of about 2 to 200 Hz.

17. A respiratory device for delivery of a medicament to a patient, comprising:

a pressurized gas source;

a nebulizer containing a medicament disposed proximal to the pressurized gas source, the nebulizer being configured to receive pressurized gas from the pressurized gas source to nebulize at least a portion of the medicament, and to direct nebulized medicament toward a breathing unit configured to deliver the medicament to the patient;

a breathing unit disposed proximal to the nebulizer and configured to deliver nebulized medicament to the patient;

a conduit disposed between the nebulizer and the breathing unit;

a compressor coupled to the conduit and configured to provide positive pressure to the breathing unit; and

a pressure sensitive switch associated with the pressurized gas source and the breathing unit, wherein the pressure sensitive switch is configured to open upon a first threshold negative pressure level to release pressurized gas, and to close upon a second threshold negative pressure level, the first and second threshold levels occurring during an inspiratory phase of a respiratory cycle.

18. The respiratory system of claim 17, wherein the second threshold negative pressure is set at a level that occurs prior to the end of an inspiratory phase of a respiratory cycle.

19. A method for nebulizing a medicament and transporting the medicament to a breathing unit, the method comprising:

providing a medicament in a respiratory system, the respiratory system including;

a pressurized gas source;

a nebulizer containing a medicament, the nebulizer being configured to receive pressurized gas from the pressurized gas source to nebulize at least a portion of the medicament, and to direct nebulized medicament toward a breathing unit configured to deliver nebulized medicament to the patient; and

a pressure sensitive switch associated with the pressurized gas source and the breathing unit, wherein the pressure sensitive switch is configured to open upon a first threshold negative pressure level to release pressurized gas, and to close upon a second threshold negative pressure level, the first and second threshold levels occurring during an inspiratory phase of a respiratory cycle; and

actuating the pressure sensitive switch to nebulize the medicament and pass the medicament to the breathing unit.

20. The method of claim 19, wherein the second threshold negative pressure is set at a level that occurs prior to the end of an inspiratory phase of a respiratory cycle.