BRANCHED POLYMERS
First Claim
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1. A branched reactive polymer having the structure:
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Y-(X)p-R(-X′
-POLY)q wherein;
R is an aliphatic hydrocarbon having a length of at least three carbon atoms;
each POLY is a poly(ethylene glycol) that terminates with a hydroxyl or methoxy group;
X′
is a heteroatom linkage selected from —
NH—
, —
O—
or —
S—
;
X is a linker of 1 to ten atoms;
p is 0 or 1;
q is 2 to about 10; and
Y is a p nitrophenyl carbonate;
and further wherein the branched reactive polymer has a molecular weight of about 500 Da to about 100,000 Da.
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Abstract
The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, -D-aryl-, (—O-alkylene-)m, or (-alkylene-O—)m linkage, wherein m is 1-10.
7 Citations
37 Claims
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1. A branched reactive polymer having the structure:
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Y-(X)p-R(-X′
-POLY)qwherein; R is an aliphatic hydrocarbon having a length of at least three carbon atoms; each POLY is a poly(ethylene glycol) that terminates with a hydroxyl or methoxy group; X′
is a heteroatom linkage selected from —
NH—
, —
O—
or —
S—
;X is a linker of 1 to ten atoms; p is 0 or 1; q is 2 to about 10; and Y is a p nitrophenyl carbonate;
and further wherein the branched reactive polymer has a molecular weight of about 500 Da to about 100,000 Da.- View Dependent Claims (2, 3, 4, 5, 6, 15, 16, 17, 37)
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7-14. -14. (canceled)
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18-36. -36. (canceled)
Specification