NUTRITIONAL AND MEDICINAL ORAL COMPOSITION FOR VETERINARY USE

• US 20160038420A1
• Filed: 03/03/2014
• Published: 02/11/2016
• Est. Priority Date: 03/04/2013
• Status: Active Grant

• Current Assignee: Virbac
• Original Assignee: Virbac
• Inventors: BRUNEL, Nicolas, MARTINS, Fanny, GOISNARD, Patricia
• Granted Patent: US 10,166,186 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A23K 20/00 Accessory food factors for animal feeding-stuffs
• CPC Class Codes: A23K 20/111 Aromatic compounds
• CPC Class Codes: A23K 20/158 Fatty acids; Fats; Products containing oils or fats
• CPC Class Codes: A23K 40/20 by moulding, e.g. making cakes or briquettes
• CPC Class Codes: A23K 40/25 by extrusion
• CPC Class Codes: A23K 40/30 by encapsulating; by coating
• CPC Class Codes: A23K 50/40 for carnivorous animals, e.g. cats or dogs
• CPC Class Codes: A61K 31/55 having seven-membered rings, e.g. azelastine, pentylenetetrazole
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61K 9/1617 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/1676 having a drug-free core with discrete complete coating layer containing drug adsorbates of liquid drug formulations on inert powders without simultaneous granulation step A61K9/141; with further drug-free outer coating A61K9/5078; drug conjugated to non-active particles A61K47/6921
• CPC Class Codes: A61K 9/1694 resulting in granules or microspheres of the matrix type containing more than 5% of excipient
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention relates to a method for producing a nutritional and medicinal oral composition for veterinary use, comprising the following steps: a) providing cores of extruded products of complete feed, and b) coating the cores of extruded products of complete feed provided in step a) with at least one layer of a fatty material comprising at least one medicinal agent, said medicinal agent comprising (i) at least one pre-conditioned active substance in the form of a solution or a suspension of said active substance in an oily liquid, or (ii) at least one pre-conditioned active substance in the form of waxy granulates, at a temperature lower than 40° C.

Claims

1. A method for obtaining a nutritional and medicinal oral composition for veterinary use comprising the following steps:

a) supplying cores of complete feed extrudate, and

b) coating the cores of complete feed extrudate supplied in step a) with at least one layer of fat comprising at least one medicinal agent, said medicinal agent comprising (i) at least one preconditioned active principle in the form of a solution or of a suspension of said active principle in an oily liquid or (ii) at least one preconditioned active principle in the form of waxy granules, at a temperature below 40°

C.

2. The method as claimed in claim 1, wherein step b) comprises the following steps:

b1) bringing the cores of complete feed extrudate into contact with at least one medicinal agent, said medicinal agent comprising (i) at least one preconditioned active principle in the form of a solution or of a suspension of said active principle in an oily liquid or (ii) at least one preconditioned active principle in the form of waxy granules, and

b2) coating the extrudate cores obtained at the end of step b1) with at least one layer of fat, at a temperature below 40°

C.

3. The method as claimed in claim 1, wherein step b) comprises the following steps:

b3) obtaining a fat composition comprising at least one medicinal agent, said medicinal agent comprising (i) at least one preconditioned active principle in the form of a solution or of a suspension of said active principle in an oily liquid or (ii) at least one preconditioned active principle in the form of waxy granules, and

b4) coating the extrudate cores obtained at the end of step a) with at least one layer of the fat composition comprising said active principle obtained at the end of step b3), at a temperature below 40°

C.

4. The method as claimed in claim 1, wherein the layer of fat comprises at least one fat of animal or vegetable origin.

5. The method as claimed in claim 1, wherein the layer of fat is solid at a temperature below 25°

C.

6. The method as claimed in claim 1, wherein the layer of fat comprises at least one fat selected from hog fat, lard, suet, duck fat or fish oil.

7. The method as claimed in claim 1, wherein the active pharmaceutical ingredient is sensitive to moisture.

8. The method as claimed in claim 1, wherein the active pharmaceutical ingredient is intended for preventing or treating a chronic disorder or disease.

9. The method as claimed in claim 1, wherein the active pharmaceutical ingredient is intended for preventing or treating renal insufficiency.

10. The method as claimed in claim 1, wherein the moisture-sensitive active pharmaceutical ingredient is selected from angiotensin-converting enzyme inhibitors (ACE inhibitors), renin inhibitors and angiotensin II receptor antagonists, firocoxib, ciclosporin, S-adenosyl-methionine, eplerenone, spironolactone, amlodipine and levosimendan.

11. The method as claimed in claim 10, wherein the angiotensin-converting enzyme inhibitors are selected from benazepril, enalapril, ramipril, quinapril, preindopril, lisinopril, imidapril, zofnopril, trandolapril, as well as salts thereof.

12. The method as claimed in claim 10, wherein the renin inhibitors are selected from pepstatin, peptide analogs of pepstain, peptide mimetics of pepstatin such as remikiren and non-peptide mimetics of pepstatin such as aliskiren, as well as salts thereof.

13. The method as claimed in claim 10, wherein the angiotensin II receptor antagonists are selected from valsartan, telmisartan, losartan, irbesartan, azilsartan and omesartan, as well as salts thereof.

14. The method as claimed in claim 1, wherein the active pharmaceutical ingredient is benazepril or a salt thereof, in particulate form.

16. A nutritional and medicinal oral composition for veterinary use, wherein it is obtained by the method as claimed in claim 1.

19. The composition as claimed in claim 16, for use as a medicinal product for veterinary use.

20. The composition as claimed in claim 16, for use for preventing or treating renal insufficiency in a nonhuman mammal.

15. A nutritional and medicinal oral composition for veterinary use comprising a core of complete feed extrudate coated with at least one layer of fat, said layer of fat comprising at least one medicinal agent, said medicinal agent comprising (i) at least one preconditioned active principle in the form of a solution or of a suspension of said active principle in an oily liquid or (ii) at least one preconditioned active principle in the form of waxy granules.

17. The composition as claimed in claim 15, for use as a medicinal product for veterinary use.

18. The composition as claimed in claim 15, for use for preventing or treating renal insufficiency in a nonhuman mammal.