PHARMACEUTICAL COMPOSITIONS COMPRISING SORBITAN ESTERS
First Claim
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1. A pharmaceutical composition comprising:
- (a) a water-insoluble antipsychotic agent;
(b) sorbitan esters of a carboxylic acid, wherein the carboxylic acid comprises 4-20 carbon atoms;
(c) a polyoxyethylene derivative of a sorbitan ester of a carboxylic acid, wherein the carboxylic acid comprises 8-14 carbon atoms; and
(d) an aqueous vehicle;
wherein the composition forms an aqueous, flocculated, injectable suspension.
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Abstract
The present invention relates to a pharmaceutical composition comprising sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.
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Citations
40 Claims
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1. A pharmaceutical composition comprising:
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(a) a water-insoluble antipsychotic agent; (b) sorbitan esters of a carboxylic acid, wherein the carboxylic acid comprises 4-20 carbon atoms; (c) a polyoxyethylene derivative of a sorbitan ester of a carboxylic acid, wherein the carboxylic acid comprises 8-14 carbon atoms; and (d) an aqueous vehicle; wherein the composition forms an aqueous, flocculated, injectable suspension. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 34, 35, 36, 37, 38, 39, 40)
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22. An injectable pharmaceutical composition comprising:
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(a) aripiprazole, or olanzapine, or a compound of formula I, II, III, IV or V, or pharmaceutically acceptable salts, hydrates, or solvates thereof, wherein component (a) is in a weight ratio of approximately 15-35%; (b) sorbitan laurate in a weight ratio of approximately 0.2-1% (c) polysorbate 20 in a weight ratio of approximately 0.05-0.8%; and (d) an aqueous carrier. - View Dependent Claims (23)
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- 24. An injectable composition comprising a water-insoluble antipsychotic agent and sorbitan esters of a carboxylic acid, wherein the carboxylic acid comprises 8-14 carbon atoms.
Specification